{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:02:15Z","timestamp":1772118135255,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We hypothesized that the frequency (in Hertz) of generalized spike\u2013waves (GSWs) in patients with idiopathic generalized epilepsy (IGE) has associations with the syndromic diagnosis as well as with the prognosis of patients (their response to medical treatment).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective study of a prospectively developed database. All patients with a diagnosis of IGE were studied at the epilepsy center at Shiraz University of Medical Sciences, Shiraz, Iran, from 2008 until 2022. Patients were classified into four IGE syndromes: childhood absence epilepsy; juvenile absence epilepsy; juvenile myoclonic epilepsy; and generalized tonic\u2013clonic seizures alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five hundred and eighty\u2010three patients were studied. GSWs were commonly observed in all four syndromes of IGE. Frequency of GSW (in Hertz) did not have a significant association with the syndromic diagnosis of the patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.179). The presence of GSW did not have a significant association with the seizure outcome (becoming seizure free or not) of the patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.416). Frequency of GSW did not have a significant association with the seizure outcome of the patients either (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.574).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>GSWs are the hallmark electroencephalographic footprints of idiopathic generalized epilepsies; however, neither their presence nor their frequency has practical associations with the syndromic diagnosis of IGEs or their outcome (response to treatment).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70023","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T03:38:37Z","timestamp":1728013117000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Generalized spike\u2013waves in idiopathic generalized epilepsies: Does their frequency matter?"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2598-7601","authenticated-orcid":false,"given":"Ali A.","family":"Asadi\u2010Pooya","sequence":"first","affiliation":[{"name":"Epilepsy Research Center Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Jefferson Comprehensive Epilepsy Center Department of Neurology Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Farazdaghi","sequence":"additional","affiliation":[{"name":"Epilepsy Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2012.08.01510.1016\/j.yebeh.2012.08.015"},{"issue":"2","key":"e_1_2_11_3_1","first-page":"25","article-title":"Is interictal EEG correlated with the seizure type in idiopathic (genetic) generalized epilepsies?","volume":"6","author":"Asadi\u2010Pooya A. 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