{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:04:23Z","timestamp":1790460263006,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Post\u2010traumatic stress disorder (PTSD) is a debilitating psychological disorder that occurs after exposure to catastrophic\u2010level experiences. Although alterations in immune function have been identified in individuals with PTSD, the causal relationship between the two remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To investigate the causal relationship between PTSD and immune function, we conducted the forward and backward two\u2010sample Mendelian randomization (MR) analyses, based on summary\u2010level genome\u2010wide association studies (GWAS) data on PTSD and immune cell traits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>For the forward MR analysis, PTSD was found to reduce the levels of CD62L\u2212 dendritic cell (DC) (beta\u00a0=\u00a0\u22120.254, FDR\u00a0=\u00a00.01), CD86+ myeloid DC (beta\u00a0=\u00a0\u22120.238, FDR\u00a0=\u00a00.014), CD62L\u2212 myeloid DC (beta\u00a0=\u00a0\u22120.26, FDR\u00a0=\u00a00.01), CD62L\u2212 CD86+ myeloid DC absolute count (beta\u00a0=\u00a0\u22120.264, FDR\u00a0=\u00a00.024), and CD62L\u2212 CD86+ myeloid DC (beta\u00a0=\u00a0\u22120.328, FDR\u00a0=\u00a00.002). In contrast, PTSD was observed to increase the level of CD28\u2212 CD8dim T\u2010cell absolute count (beta\u00a0=\u00a00.27, FDR\u00a0=\u00a00.029). For the backward MR analysis, the odds ratio (OR) for CD33 on CD33dim HLA DR+ CD11b\u2212 in relation to PTSD risk was found to be 1.045 (95% CI\u00a0=\u00a01.021\u20131.069, FDR\u00a0=\u00a00.008). The OR for FSC\u2010A on HLA DR+ CD8br was 1.048 (95% CI\u00a0=\u00a01.018\u20131.079, FDR\u00a0=\u00a00.039) and for CCR2 on CD14\u2212 CD16+ monocyte was 1.059 (95% CI\u00a0=\u00a01.027\u20131.092, FDR\u00a0=\u00a00.008). No significant pleiotropy was detected in both forward and backward MR analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The bidirectional MR study shed light on the intricate interplay between immune function and PTSD. The identification of a bidirectional causal relationship between T cells and PTSD opens new avenues for considering innovative approaches to the prevention and early intervention of PTSD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70073","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T02:53:11Z","timestamp":1727751191000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Causal Relationship Between Post\u2010Traumatic Stress Disorder and Immune Cell Traits: A Mendelian Randomization Study"],"prefix":"10.1002","volume":"14","author":[{"given":"Jian","family":"Wang","sequence":"first","affiliation":[{"name":"Shenzhen Mental Health Center Shenzhen Kangning Hospital  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Shao","sequence":"additional","affiliation":[{"name":"Shenzhen Mental Health Center 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