{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T03:28:15Z","timestamp":1789270095664,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Poor quality sleep has often been cited as a cause of lowered quality of life in patients with affective disorders such as major depressive disorder (MDD) and generalized anxiety disorder (GAD). As sleep and affective disorders are affected by multi\u2010network interactions, we hypothesize that the modulation of the central executive network (CEN), salience, and default mode networks (DMNs) through individualized repetitive transcranial magnetic stimulation (rTMS) may improve sleep and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis from 2020 to 2023 was conducted in patients with affective disorders at Cingulum Health. Multiple targets were selected based on anomalies detected from individual, functional connectivity networks from a machine\u2010learning connectivity software. rTMS was conducted with accelerated continuous or intermittent theta burst stimulation (TBS) based on the anomaly detected. Pittsburgh Sleep Quality Index (PSQI), EuroQol (EQ5D), Beck's Depression Inventory (BDI), and the General Anxiety Disorder\u20107 (GAD\u20107) questionnaires were administered prior to, after, and at follow\u2010up of rTMS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010seven patients were identified, and the most common diagnoses were MDD (41%) or MDD with GAD (41%). All patients had at least one rTMS target in the CEN. The most common target (19 patients) was L8Av in the dorsolateral prefrontal cortex (dlPFC). Patients experienced significant improvements in sleep, quality of life, depressive, and anxiety symptoms after rTMS and during follow\u2010up. Improvements in sleep correlated with quality of life at follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study suggests that personalized, parcel\u2010guided rTMS is safe and may provide sustained improvements in sleep, quality of life, and affective symptoms for patients with affective disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70088","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T03:41:21Z","timestamp":1729136481000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Improvements in Sleep Quality in Patients With Major Depressive and Generalized Anxiety Disorders Treated With Individualized, Parcel\u2010Guided Transcranial Magnetic Stimulation"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5136-7353","authenticated-orcid":false,"given":"Si Jie","family":"Tang","sequence":"first","affiliation":[{"name":"School of Medicine University of California Davis Medical Center  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Holle","sequence":"additional","affiliation":[{"name":"Cingulum Health  Rosebery Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirjan","family":"Mor","sequence":"additional","affiliation":[{"name":"School of Medicine University of California Davis Medical Center  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas B.","family":"Dadario","sequence":"additional","affiliation":[{"name":"Robert Wood Johnson Medical School Rutgers University  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Ryan","sequence":"additional","affiliation":[{"name":"Cingulum Health  Rosebery Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Teo","sequence":"additional","affiliation":[{"name":"Cingulum Health  Rosebery Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5407-2585","authenticated-orcid":false,"given":"Michael","family":"Sughrue","sequence":"additional","affiliation":[{"name":"Cingulum Health  Rosebery Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacky","family":"Yeung","sequence":"additional","affiliation":[{"name":"Cingulum Health  Rosebery Australia"},{"name":"Department of Neurosurgery Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.12740\/PP\/68503"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1087\u20100792(97)90005\u20108"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2646"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/31.4.473"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13010139"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22894"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1063408"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682\u2010021\u201000567\u20109"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.9846"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2012.02.005"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acn.2007.01.021"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.07.041"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14170"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2021.101569"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2023.105126"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18933"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520\u20106394(1996)4:4<160::AID\u2010DA2>3.0.CO;2\u2010J"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.12.033"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2019.05.008"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1037\/0021\u2010843X.117.1.182"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.118375"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u201012\u2010819410\u20102.00004\u20107"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2022.101735"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133959"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263\u2010019\u201000662\u2010y"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010017\u20105012\u20108"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910\u2010018\u20100861\u20103"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.08.003"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010020\u201000970\u20108"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2020.01.028"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.01.018"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.859440"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2010.03.006"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2021.04.010"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2012.09.011"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2009.08.016"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2019.19090915"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2019.01.007"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2018.12.041"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2019.109763"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060\u2010022\u201004160\u2010y"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12948"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.01.032"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010021\u201001441\u20104"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12953"},{"issue":"12","key":"e_1_2_13_47_1","first-page":"758","article-title":"The Extraordinary Importance of Sleep: The Detrimental Effects of Inadequate Sleep on Health and Public Safety Drive an Explosion of Sleep Research","volume":"43","author":"Worley S. L.","year":"2018","journal-title":"Pharmacy and Therapeutics"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4048916"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2018.1483"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.19105"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2914"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2018.05.013"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2016.05.011"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijos.2015.35"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.70088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T15:17:01Z","timestamp":1730128621000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.70088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":53,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/brb3.70088"],"URL":"https:\/\/doi.org\/10.1002\/brb3.70088","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.70088\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70088\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70088\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70088\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70088\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70088\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70088\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70088\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70088\/v1\/decision1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2024-06-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70088"}}