{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T03:53:06Z","timestamp":1780717986288,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Speech impairment is a recognized but unpredictable adverse effect of sub\u2010thalamic nucleus deep brain stimulation (STN\u2010DBS) for Parkinson's disease (PD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the prevalence of speech impairment 1 year after STN\u2010DBS in PD patients and to determine the predictive factors for speech outcome following STN\u2010DBS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data for 417 patients from the French national PREDISTIM study were collected preoperatively. The combined effect of medical treatment and surgery on speech was compared using specific items from dedicated clinical scales (MDS\u2010UPDRS III.1: primary endpoint) and patient self\u2010assessment questionnaires (items 34 and 35 of the PDQ39: secondary endpoints). For each variable, three patient groups were generated according to speech outcome at 1 year: worsening, stability, and improvement. In the second step analysis, the three groups were compared for demographic and clinical variables at baseline and STN\u2010DBS parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was a significant deterioration in speech of all considered items 1 year after combined STN\u2010DBS and dopaminergic treatment. Four predictive factors for speech deterioration were detected: (i) the absence of preoperative speech impairment (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001); (ii) severity of motor activity of daily living (MDS\u2010UPDRS II off total score) (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.037); (iii) high\u2010intensity stimulation of the left electrode (i.e., above 3.6\u00a0V) (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.046); and (iv) the absence of any change in non\u2010motor experiences of daily life (MDS\u2010UPDRS I total score) (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.048).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Speech outcome should be carefully monitored after STN\u2010DBS, especially in PD patients without preoperative speech impairment, with motor difficulties in daily\u2010living activities, and with increased left electrode intensity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov identifier: NCT02360683.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70101","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:44:46Z","timestamp":1745973886000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Parkinson's Disease, Speech and Neurosurgery"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3609-5211","authenticated-orcid":false,"given":"Thomas","family":"Ollivier","sequence":"first","affiliation":[{"name":"CHU Lille Department of Medical Pharmacology University of Lille, Lille Neuroscience and Cognition INSERM, U1172, LiCEND, NS\u2010Park\/F\u2010CRIN Network  Lille France"},{"name":"Neurology and Movement Disorders Department Expert Center for Parkinson's Disease, Lille University Medical Center  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Pinto","sequence":"additional","affiliation":[{"name":"CNRS, LPL, Aix\u2010Marseille Universit\u00e9  Aix\u2010en\u2010Provence France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Sophie","family":"Rolland","sequence":"additional","affiliation":[{"name":"CHU Lille Department of Medical Pharmacology University of Lille, Lille Neuroscience and Cognition INSERM, U1172, LiCEND, NS\u2010Park\/F\u2010CRIN Network  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emeline","family":"Cailliau","sequence":"additional","affiliation":[{"name":"Biostatistics Department CHU Lille  Lille 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