{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:02:53Z","timestamp":1772118173191,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tremor\u2010dominant (TD) and nontremor\u2010dominant (NTD) Parkinson's disease (PD) showed different responses to rehabilitation. However, the neural mechanism behind this remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cohort study explores changes in motor function, brain activation, and functional connectivity following 2 weeks of rehabilitation in TD\u2010PD and NTD\u2010PD patients, respectively. A total of 11 TD\u2010PD patients, 24 NTD\u2010PD patients, and 21 age\u2010matched healthy controls (HCs) were included. At baseline, all participants underwent functional magnetic resonance imaging (fMRI) while performing the foot tapping task. Motor symptoms, gait, balance, and task\u2010based fMRI were then evaluated in patients before and after rehabilitation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to HCs, TD\u2010PD patients showed increased activity in the left inferior frontal gyrus and the right insula, and NTD\u2010PD patients showed increased activations in the left postcentral gyrus and decreased within\u2010cerebellar connectivity at baseline. Rehabilitation improved motor function in PD patients regardless of motor subtype. TD\u2010PD patients showed increased recruitments of the sensorimotor cortex and the bilateral thalamus after rehabilitation, and NTD\u2010PD patients showed increased cerebellar activation and within\u2010cerebellar connectivity that was associated with better motor performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrated that rehabilitation\u2010induced brain functional reorganization varied by motor subtypes in PD, which may have important implications for making individualized rehabilitation programs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov identifier: ChiCTR1900020771<\/jats:p>\n                  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