{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T03:19:04Z","timestamp":1775186344404,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This meta\u2010analysis aimed to evaluate the comparative diagnostic performance of amyloid\u2010\u03b2 positron emission tomography (A\u03b2 PET) and magnetic resonance imaging (MRI) in diagnosing Alzheimer's disease (AD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An extensive search was conducted in the PubMed and Embase databases to identify available publications up to December 2023. Head\u2010to\u2010head comparative studies were included if they evaluated the diagnostic performance of A\u03b2 PET and MRI in diagnosing Alzheimer's disease. Sensitivity and specificity were assessed using the DerSimonian and Laird method, followed by transformation via the Freeman\u2013Tukey double inverse sine transformation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Six articles involving 560 patients were included in the meta\u2010analysis. When distinguishing AD from mild cognitive impairment (MCI), both methods showed comparable sensitivity (A\u03b2 PET: 0.71, MRI: 0.62) and specificity (A\u03b2 PET: 0.68, MRI: 0.69), with no statistically significant differences observed (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.34 and 0.99). When identifying AD from normal cognitive control (NC), both A\u03b2 PET and MRI showed similar results, with comparable sensitivity (A\u03b2 PET: 0.93, MRI: 0.85) and specificity (A\u03b2 PET: 0.95, MRI: 0.82), without significant differences (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.38 and 0.19). Similarly, in detecting MCI from NC, both A\u03b2 PET and MRI demonstrated similar sensitivity (A\u03b2 PET: 0.69, MRI: 0.64) and specificity (A\u03b2 PET: 0.75, MRI: 0.76) without significant differences (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.40 and 0.94). However, 18F\u2010FMM seems to have a higher specificity compared to MRI when distinguishing AD from MCI (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.03) and AD from NC (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our meta\u2010analysis indicates that A\u03b2 PET demonstrates similar sensitivity and specificity to MRI in diagnosing Alzheimer's disease. However, the limited number of studies may impact the evidence of the current study; further larger sample prospective research is required to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70111","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T05:55:29Z","timestamp":1729576529000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparative Diagnostic Performance of Amyloid\u2010\u03b2 Positron Emission Tomography and Magnetic Resonance Imaging in Alzheimer's Disease: A Head\u2010to\u2010Head Meta\u2010Analysis"],"prefix":"10.1002","volume":"14","author":[{"given":"Fang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology General Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurology General Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaihui","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Neurology General Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology General Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology General Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology General Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4223-9116","authenticated-orcid":false,"given":"Xiaolu","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Radiology General Hospital of Ningxia Medical University  Yinchuan China"},{"name":"School of Health Sciences Universiti Sains Malaysia  Kubang Kerian Kelantan Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13016"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u20102011\u2010110458"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010022\u201001117\u20101"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25245789"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.05.1762"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474\u20104422(20)30314\u20108"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010019\u20100333\u20105"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2009.215"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610211001220"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2016.1277197"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn016"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010013\u20101185\u20107"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533317518791401"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23116079"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci10080479"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000023969"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1586\/ern.10.162"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.19163"},{"key":"e_1_2_12_20_1","doi-asserted-by":"crossref","unstructured":"Mikhno A. 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