{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:28:00Z","timestamp":1788931680097,"version":"build-2803163510"},"reference-count":134,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Dexmedetomidine, a highly specific \u03b12 agonist, has been extensively utilized in clinical sedation and surgical anesthesia since its introduction in 2000 due to its excellent sympatholytic, sedative, and analgesic effects. This review aimed to identify new approaches for the treatment of patients with brain disorders by thoroughly describing the mechanism of action of dexmedetomidine and examining its neuroprotective effects from the standpoints of basic and clinical research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The PubMed and Web of Science databases were searched using the keywords dexmedetomidine and related brain diseases, although relevant articles from the last decade were included for detailed summarization and analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Dexmedetomidine has shown strong neuroprotective effects, such as protection of the blood\u2010brain barrier, decreased neuronal death, maintained hemodynamic stability, and reduced postoperative agitation and cognitive dysfunction. Furthermore, dexmedetomidine has been shown to exert various neuroprotective effects, including anti\u2010inflammatory and antioxidative stress effects, modulation of autophagy, and reduction of apoptosis in cerebral diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Dexmedetomidine acts as a neuroprotective agent against brain diseases during all phases of treatment. However, clinical trials with larger sample sizes are required to optimize dosage and dosing strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70116","type":"journal-article","created":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T01:36:19Z","timestamp":1730424979000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Progress on the Mechanisms and Neuroprotective Benefits of Dexmedetomidine in Brain Diseases"],"prefix":"10.1002","volume":"14","author":[{"given":"Zhenxing","family":"Tao","sequence":"first","affiliation":[{"name":"Wuxi Medical School Jiangnan University  Wuxi China"},{"name":"Department of Neurosurgery Jiangnan University Medical Center  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengpeng","family":"Li","sequence":"additional","affiliation":[{"name":"Wuxi Medical School Jiangnan University  Wuxi China"},{"name":"Department of Neurosurgery Jiangnan University Medical Center  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3568-1649","authenticated-orcid":false,"given":"Xudong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Jiangnan University Medical Center  Wuxi China"},{"name":"Wuxi Neurosurgical Institute  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.5863\/1551\u20106776\u201029.3.232"},{"issue":"11","key":"e_1_2_11_3_1","article-title":"Acute Colonic Pseudo\u2010Obstruction Following the Use of Dexmedetomidine","volume":"13","author":"Alkaissi H. R.","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2013.02.010"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.596718"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2018.09.016"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2024.2327143"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11112199"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6643171"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.1957071"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S140644"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2022.106896"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jopan.2023.10.006"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S158737"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.12300"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00045.2019"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064\u2010022\u201003712\u2010y"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000017012"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.555532"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2020.1833154"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.16357.1"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010031\u201026163\u20103_9"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13041\u2010015\u20100105\u20102"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.977941"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/03000605211062789"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2023.2209735"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/CON.0000000000000416"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.4097\/kja.22165"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5126042"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/ANA.0000000000000907"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.11817\/j.issn.1672\u20107347.2022.210443"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.965661"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevEukaryotGeneExpr.2021037390"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.2217\/pme\u20102019\u20100003"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2019.01.016"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787\u2010021\u201000877\u2010w"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.10906"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2013.1301"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.4097\/kja.2220"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.16152"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010319\u201073739\u20103_11"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13663"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028\u2010021\u201001381\u20103"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09541-4"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.13424"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.11.146"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2018.10.004"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.50878"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103975"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063\u2010023\u201007632\u20102"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.2147\/CPAA.S436188"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871\u2010022\u201001574\u2010z"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2017.04.039"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11070846"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/08971900211027133"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.5607\/en.2018.27.4.267"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0102\u2010865020170060000006"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2018.09.007"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/ANA.0000000000000728"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1590\/1414\u2010431X2022e12145"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2022.136842"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20191994"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064\u2010022\u201003597\u2010x"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000006106"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsyn.2022.891803"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.714996"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00197"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1135\u201014.2014"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1097\/ANA.0000000000000797"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.10.008"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6889676"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2017.1281197"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2017.10.034"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571\u2010015\u20100315\u20102"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100043\u20101761491"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.5114\/fn.2023.131556"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-022-01067-x"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.2174\/0109298665254683231122065717"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0091\u20103057(96)00127\u2010x"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00858"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102377\u201012\u201020"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59091518"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10479"},{"issue":"13","key":"e_1_2_11_84_1","first-page":"4574","article-title":"Dexmedetomidine Inhibits Cerebral Nerve Cell Apoptosis After Cerebral Hemorrhage in Rats via the Nrf2\/HO\u20101\/NQO1 Signaling Pathway","volume":"26","author":"Shao G.","year":"2022","journal-title":"European Review for Medical and Pharmacological Sciences"},{"issue":"6","key":"e_1_2_11_85_1","article-title":"Dexmedetomidine as an Adjunct in a Fluoroscopically Guided Stellate Ganglion Block for Complex Regional Pain Syndrome","volume":"15","author":"Sheikh H.","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5463986"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000281916.65365.4e"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.5812\/aapm.113802"},{"issue":"6","key":"e_1_2_11_89_1","first-page":"2612","article-title":"Therapeutic Effect of Dexmedetomidine on Intracerebral Hemorrhage via Regulating NLRP3","volume":"23","author":"Song H. L.","year":"2019","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1097\/ANA.0000000000000504"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540\u2010014\u20101952\u20101"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2020.146682"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2021.05.006"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010019\u20101416\u20105"},{"issue":"7","key":"e_1_2_11_95_1","first-page":"2724","article-title":"Exploring the Impact of Dexmedetomidine on Short\u2010Term Outcomes in Critically Ill Sepsis\u2010Associated Encephalopathy Patients","volume":"28","author":"Tang J.","year":"2024","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2019.03.232"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-019-02612-w"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.4103\/jnrp.jnrp_310_17"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60153-6"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14695"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001\u2010024\u201001838\u2010z"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.1999369"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00019.2023"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010\u2010020\u201003726\u20106"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm\u201022\u20106639"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b21-00329"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.5137\/1019\u20105149.JTN.36585\u201021.2"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aev549"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.28058"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.899484"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25847"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2017.04.016"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1080\/08923973.2022.2069577"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S378893"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1159\/000521737"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118980"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.08.011"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.204648"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2011.01.013"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2021.106021"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1080\/08923973.2021.1942901"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2019.10718"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000006563"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.918617"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2018.8898"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1379019"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.21037\/apm\u201021\u20101218"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3711"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00330"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871\u2010020\u201001211\u20107"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110440"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmab092"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12017\u2010019\u201008576\u20100"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753\u2010019\u201001082\u20102"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.12213"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.70116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T07:26:24Z","timestamp":1733297184000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.70116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,31]]},"references-count":134,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/brb3.70116"],"URL":"https:\/\/doi.org\/10.1002\/brb3.70116","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.70116\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70116\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70116\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70116\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70116\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70116\/v1\/decision1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,31]]},"assertion":[{"value":"2024-07-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70116"}}