{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:37:34Z","timestamp":1791859054238,"version":"4.3.4"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>Around 30% of patients with epilepsy show drug\u2010resistant epilepsy (DRE). While cannabidiol has demonstrated efficacy as an adjunctive treatment in Dravet syndrome (DS), Lennox\u2013Gastaut Syndrome (LGS), and epilepsy related to tuberous sclerosis complex (TSC), its more global effectiveness in adult patients with DRE apart from these three specific contexts needs to be clarified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective study at the epilepsy unit of Piti\u00e9 Salp\u00eatri\u00e8re Hospital. Patients initiating pharmaceutical cannabidiol treatment and followed for at least 1 year were included. Patients were categorized into \u201cauthorized\u201d (LGS, DS, or TSC) and \u201coff\u2010label\u201d groups. Cannabidiol effectiveness and tolerance were compared between groups, and characteristics of responders (patients with &gt;50% reduction in seizure frequency) in the off\u2010label group were examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010one patients, followed by a median duration of 24 months, were included. A total of 35.2% of the patients were in the authorized group. No significant differences were observed in responder rates between groups (31.3% vs. 35.6%,\n                      <jats:italic>p<\/jats:italic>\n                      =\u00a00.85) and retention rates at 1 year (75.0% vs. 74.6%,\n                      <jats:italic>p<\/jats:italic>\n                      =\u00a00.97). Sleepiness was more commonly reported in the authorized group (50.0% vs. 22.0%,\n                      <jats:italic>p<\/jats:italic>\n                      =\u00a00.01), with no other significant differences. Among off\u2010label patients (\n                      <jats:italic>n<\/jats:italic>\n                      = 59), clobazam co\u2010prescription was more prevalent in responders (71.4% vs. 28.9%,\n                      <jats:italic>p<\/jats:italic>\n                      =\u00a00.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that cannabidiol may benefit all adult patients with DRE, particularly those already receiving clobazam. Randomized controlled trials are warranted in off\u2010label patients to validate these observational findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70122","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T01:14:06Z","timestamp":1730855646000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cannabidiol Treatment for Adult Patients with Drug\u2010Resistant Epilepsies: A Real\u2010World Study in a Tertiary Center"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5874-3947","authenticated-orcid":false,"given":"Quentin","family":"Calonge","sequence":"first","affiliation":[{"name":"AP\u2010HP, Epilepsy Unit, Department of Neurology, Reference Center of Rare Epilepsies ERN\u2010EpiCare, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"},{"name":"Paris Brain Institute, ICM, Inserm, CNRS Sorbonne Universit\u00e9  Paris France"},{"name":"AP\u2010HP, EEG Unit, Department of Neurophysiology Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurore","family":"Besnard","sequence":"additional","affiliation":[{"name":"AP\u2010HP, Epilepsy Unit, Department of Neurology, Reference Center of Rare Epilepsies ERN\u2010EpiCare, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"},{"name":"Paris Brain Institute, ICM, Inserm, CNRS Sorbonne Universit\u00e9  Paris France"},{"name":"AP\u2010HP, EEG Unit, Department of Neurophysiology Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Bailly","sequence":"additional","affiliation":[{"name":"AP\u2010HP, Epilepsy Unit, Department of Neurology, Reference Center of Rare Epilepsies ERN\u2010EpiCare, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Damiano","sequence":"additional","affiliation":[{"name":"AP\u2010HP, Epilepsy Unit, Department of Neurology, Reference Center of Rare Epilepsies ERN\u2010EpiCare, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"},{"name":"Paris Brain Institute, ICM, Inserm, CNRS Sorbonne Universit\u00e9  Paris France"},{"name":"AP\u2010HP, EEG Unit, Department of Neurophysiology Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phintip","family":"Pichit","sequence":"additional","affiliation":[{"name":"AP\u2010HP, Epilepsy Unit, Department of Neurology, Reference Center of Rare Epilepsies ERN\u2010EpiCare, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"},{"name":"AP\u2010HP, EEG Unit, Department of Neurophysiology Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2080-8253","authenticated-orcid":false,"given":"Sophie","family":"Dupont","sequence":"additional","affiliation":[{"name":"AP\u2010HP, Epilepsy Unit, Department of Neurology, Reference Center of Rare Epilepsies ERN\u2010EpiCare, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"},{"name":"Paris Brain Institute, ICM, Inserm, CNRS Sorbonne Universit\u00e9  Paris France"},{"name":"Rehabilitation Unit, AP\u2010HP Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Gourfinkel\u2010An","sequence":"additional","affiliation":[{"name":"AP\u2010HP, Epilepsy Unit, Department of Neurology, Reference Center of Rare Epilepsies ERN\u2010EpiCare, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0077-8114","authenticated-orcid":false,"given":"Vincent","family":"Navarro","sequence":"additional","affiliation":[{"name":"AP\u2010HP, Epilepsy Unit, Department of Neurology, Reference Center of Rare Epilepsies ERN\u2010EpiCare, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"},{"name":"Paris Brain Institute, ICM, Inserm, CNRS Sorbonne Universit\u00e9  Paris France"},{"name":"AP\u2010HP, EEG Unit, Department of Neurophysiology Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16355"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611618"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1714631"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2023.09.015"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2023.109409"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003509"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2023.109159"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2020.1135"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12699"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16546"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263\u2010021\u201000807\u2010y"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2023.07.012"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(23)00151\u20105"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.4607"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)30136\u20103"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.70122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T07:25:34Z","timestamp":1733297134000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.70122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/brb3.70122"],"URL":"https:\/\/doi.org\/10.1002\/brb3.70122","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.70122\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70122\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70122\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70122\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70122\/v1\/review1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"2024-07-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70122"}}