{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:14:06Z","timestamp":1788250446581,"version":"build-2803163510"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,9]],"date-time":"2025-03-09T00:00:00Z","timestamp":1741478400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Studies in MS and NMOSD have shown that relapses can frequently occur in the same location as the first attack. Factors associated with this outcome in MOGAD are unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study was to investigate the likelihood of a relapse occurring at the same site in MOGAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a UK national cohort study. MOGAD patients with a minimum of one relapse and one year of follow\u2010up were included. To identify factors associated with relapse location, logistic regression was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      An increased risk of a relapse in the same location was observed when the first attack was optic neuritis\u2014for the second attack (OR 12.9, 95% CI 3.31\u201350.55,\n                      <jats:italic>p<\/jats:italic>\n                      =\u00a0.001) and all subsequent attacks (OR 5.39 95% CI 1.61\u201318.03,\n                      <jats:italic>p<\/jats:italic>\n                      =\u00a0.006). Conversely, a reduced risk of relapse in the same location was associated with transverse myelitis\u2014for the second attack (OR 0.25, 95% CI 0.07\u20130.82,\n                      <jats:italic>p<\/jats:italic>\n                      =\u00a0.022) and all subsequent attacks (OR 0.25 95% CI 0.06\u20130.96,\n                      <jats:italic>p<\/jats:italic>\n                      =\u00a0.045).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In relapsing MOGAD, patients with optic neuritis are at high risk of a new attack in the same location, while those with transverse myelitis are at low risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70127","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T17:53:07Z","timestamp":1741715587000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Opposing Influences of Optic Neuritis and Transverse Myelitis on the Future Location of Relapses in MOG Antibody\u2013Associated Disease"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5238-5585","authenticated-orcid":false,"given":"Daniel Lordelo","family":"San Martin","sequence":"first","affiliation":[{"name":"NMOSD National Service Walton Centre Foundation Trust  Liverpool UK"},{"name":"Postgraduate Program in Health Sciences Federal University of Bahia  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Baruch","family":"Portela Filho","sequence":"additional","affiliation":[{"name":"Deparment of Life Science State University of Bahia  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Rocchi","sequence":"additional","affiliation":[{"name":"NMOSD National Service Walton Centre Foundation Trust  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahd","family":"Hamid","sequence":"additional","affiliation":[{"name":"NMOSD National Service Walton Centre Foundation Trust  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saif","family":"Huda","sequence":"additional","affiliation":[{"name":"NMOSD National Service Walton Centre Foundation Trust  Liverpool 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