{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:00:54Z","timestamp":1772118054847,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T00:00:00Z","timestamp":1733443200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 110\u20102635\u2010B\u2010241\u2010001"],"award-info":[{"award-number":["MOST 110\u20102635\u2010B\u2010241\u2010001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Migraine is a chronic, recurring, and disabling disease. Fish oil intervention was used to investigate its effects on headache symptoms and blood lipids of migraine patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>All subjects were collected at the Kuang Tian General Hospital from March 2020 to May 2021. Experimental group subjects took 1\u00a0g\/time of fish oil (including EPA 900\u00a0mg\/tablet) after breakfast and dinner. Placebo group subjects took 100% soybean oil twice daily. Before and after the test, the migraine improvement questionnaire was used to analyze headaches during attacks, dietary intake, and headache triggers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The average age of the 47 subjects in this study was 40.3 \u00b1 9.2 years old, the body mass index (BMI) was 24.3 \u00b1 6.0\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . At Week 12, subjects in the fish oil group were significantly improved relative to the control group (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05).\n                      <jats:italic>Blood lipid indexes TC, LDL\u2010C, and TG were reduced, and the frequency, duration, and pain degree of migraine<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Fish oil may be used as an adjunctive therapeutic food for relieving migraine attack symptoms and blood lipids.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70149","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T21:45:01Z","timestamp":1733521501000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility of Fish Oil Supplementation on Headache Symptoms and Blood Lipids in Migraine Patients"],"prefix":"10.1002","volume":"14","author":[{"given":"En\u2010Ling","family":"Yeh","sequence":"first","affiliation":[{"name":"Department of Nutrition Hungkuang University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Pai","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nutrition Hungkuang University Taichung Taiwan"},{"name":"Department of Neurology Kuang Tien General Hospital Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu\u2010Wen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Nutrition Kuang Tien General Hospital Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1361-1486","authenticated-orcid":false,"given":"Hsueh\u2010Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nutrition Hungkuang University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_9_19"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17041191"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000225186.76323.69"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12482"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90828-3"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu2030355"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000022253"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.1999.3905335.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665111000061"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2008000400011"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2015"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003205.pub2"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13836"},{"issue":"1","key":"e_1_2_11_16_1","first-page":"33","article-title":"Medical Treatment Guidelines for Preventive Treatment of Migraine","volume":"26","author":"Huang T. 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