{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:02:50Z","timestamp":1772118170633,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The size of unruptured intracranial aneurysms (UIA) remains the most crucial risk factor for treatment decisions. On the other side, there is a non\u2010negligible portion of small ruptured IA and large stable UIA. This study aimed to identify the patients' characteristics related to IA size in the context of IA rupture status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 2152 patients, with 1002 being hospitalized for an acute aneurysmal subarachnoid hemorrhage (SAH), were included from our institutional IA database. Different demographic and clinical characteristics of patients and IA were collected. IA size was the study endpoint, assessed as continuous variable in univariate and multivariable linear regression analysis, separately for ruptured (R) IA and UIA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean IA size was 8.3 and 7.3\u00a0mm in the UIA and RIA subpopulations, respectively. Higher age (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.003) and baseline blood urea level (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) were independently associated with increasing UIA size. In contrast, location at the posterior circulation (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), familiar intracranial aneurysms (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), serum potassium (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.006), and total serum protein (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.019) were related to smaller UIA size in the multivariate analysis. For RIA, a statistically significant and independent association was detected for location (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.019), history of gastrointestinal diseases (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.042), and levothyroxine intake (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Identification of clinical characteristics related to the size of ruptured and unruptured IA allows a more differentiated view on the genesis of RIA and UIA and the value of sack size as a basis for therapeutic decision\u2010making. More research is needed to verify the identified risk factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70161","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T08:14:08Z","timestamp":1732781648000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Patients' Characteristics Associated With Size of Ruptured and Unruptured Intracranial Aneurysms"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7009-9099","authenticated-orcid":false,"given":"Thiemo Florin","family":"Dinger","sequence":"first","affiliation":[{"name":"Department of Neurosurgery and Spine Surgery, and Center for Translational Neuroscience and Behavioral Science (C\u2010TNBS), University Hospital of Essen University of Duisburg\u2010Essen  Essen North Rhine\u2010Westphalia 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Behavioral Science (C\u2010TNBS), University Hospital of Essen University of Duisburg\u2010Essen  Essen North Rhine\u2010Westphalia Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6616-5313","authenticated-orcid":false,"given":"Alejandro Nicolas","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Spine Surgery, and Center for Translational Neuroscience and Behavioral Science (C\u2010TNBS), University Hospital of Essen University of Duisburg\u2010Essen  Essen North Rhine\u2010Westphalia Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mats Leif","family":"Moskopp","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Faculty of Medicine and University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden  Dresden Germany"},{"name":"Institute of Physiology, Medical Faculty Carl Gustav Carus Technische Universit\u00e4t Dresden  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