{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:55:52Z","timestamp":1780707352859,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T00:00:00Z","timestamp":1733443200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2501200"],"award-info":[{"award-number":["2021YFC2501200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sequential working memory refers to the cognitive ability to maintain and\/or manipulate a set of ordered representations within a short period. It remains unclear whether sequential working memory is impaired in patients with young onset Parkinson's disease (YOPD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study is to evaluate the sequential working memory in patients with YOPD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty\u2010three YOPD patients (29 women) and one hundred age\u2010 and education\u2010matched healthy controls participated in three well\u2010established sequential working memory tests. The YOPD patients were\u00a0categorized into akinetic rigid type (PD\u2010ART) and non\u2010akinetic rigid type (PD\u2010NART). Participants were asked to maintain digit sequences in mind in the digit span forward (DST\u2010F) and to maintain and manipulate digit sequences in mind in the digit span backward (DST\u2010B) and adaptive digit ordering tests (DOT\u2010A).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The PD\u2010ART group scored lower and had higher ordering costs (difference between the DST\u2010F and DOT\u2010A scores) than the healthy control group in the DOT\u2010A. Moreover, in the PD\u2010ART group, the daily levodopa equivalent dose for dopamine D2\/3 receptor agonists positively correlated with the DOT\u2010A score and negatively correlated with the DOT\u2010A ordering cost, suggesting that patients who took a greater dose of dopamine D2\/3 receptor agonists tended to have higher DOT\u2010A scores and lower DOT\u2010A ordering costs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results indicated that the impaired sequential working memory may be one of markers of identifying early cognitive impairment in patients with YOPD, especially in PD\u2010ART patients. The dopamine D2\/3 receptor agonists can recover this impairment to some extent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70182","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T21:24:53Z","timestamp":1733520293000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impaired Sequential Working Memory in Patients With Young Onset Parkinson's Disease"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0965-218X","authenticated-orcid":false,"given":"Guanyu","family":"Zhang","sequence":"first","affiliation":[{"name":"China Institute of Sport Science Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Taian Hospital of Traditional Chinese Medicine Taian 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