{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T18:29:37Z","timestamp":1782584977500,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:00:00Z","timestamp":1735603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Duloxetine, a serotonin and norepinephrine reuptake inhibitor (SNRI), is used to treat various health conditions, including major depressive disorder, generalized anxiety disorder, fibromyalgia, and off\u2010label for chemotherapy\u2010induced pain. We conducted this systematic review and meta\u2010analysis aiming to test the current evidence regarding effectiveness and safety of duloxetine for postspine surgeries pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched the Cochrane Central Register of Controlled Trials, PubMed, Scopus and Web of science databases for relevant articles up to March 2024. The following search terms were Used in combination using the Boolean operators ((Duloxetine Hydrochloride) AND ((Pain, Postoperative) OR (Postoperative Period) OR (Postoperative Cognitive Complications) OR (Delayed Emergence from Anesthesia) OR (Postoperative Care) OR (spine surgery)) without time constrain for the search. Meta\u2010analysis was performed using Review Manager (RevMan version 5.4) on the extracted outcome data that present in at least 3 of the included studies. Mean difference (MD) was used as the effect size for continuous outcomes with a 95% confidence interval (CI) or standardized mean difference (SMD) in case of different outcome reporting scales.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pooled analysis showed that duloxetine significantly reduces pain intensity after 24 h from the operation compared to placebo (SMD = \u22121.11, 95% CI [\u22122.16 to \u22120.07], <jats:italic>p<\/jats:italic> = 0.04) with no significant difference in pain after 2 and 48 h. Meta\u2010analysis revealed that duloxetine shows a significant reduction in the amount of analgesic consumption after 24\u00a0h postoperative; (MD = \u22123.33, 95% CI [\u22125.53 to \u22121.13], <jats:italic>p<\/jats:italic> = 0.003). The analysis did not show any statistically significant difference between duloxetine and placebo in patients experiencing nausea or vomiting (RR = 1.37, 95% CI [0.62 to 3.00]<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings of this study suggest that duloxetine may be effective in reducing pain 24\u00a0h after spine surgery. Furthermore, there is a promising effect of duloxetine in treating chronic postoperative pain. However, it is important to acknowledge that further research is warranted to thoroughly evaluate the efficacy and safety of duloxetine for relieving chronic postoperative pain.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.70217","type":"journal-article","created":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:24:16Z","timestamp":1735691056000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy of Duloxetine for Postspine Surgery Pain: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"15","author":[{"given":"Abdulsalam Mohammed","family":"Aleid","sequence":"first","affiliation":[{"name":"Department of Surgery, Medical College King Faisal University Hofuf, Ahsa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal","family":"Alshehri","sequence":"additional","affiliation":[{"name":"Department of surgery King Khalid University Abha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naif","family":"Alasiri","sequence":"additional","affiliation":[{"name":"Department of surgery King Khalid University Abha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatimah","family":"Alhomoud","sequence":"additional","affiliation":[{"name":"Department of surgery Imam Abdulrahman Bin Faisal University Dammam Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouq","family":"Alsaegh","sequence":"additional","affiliation":[{"name":"Department of surgery Qassim University Unaizah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Alrasheed","sequence":"additional","affiliation":[{"name":"Department of surgery King Saud Bin Abdulaziz University for Health Sciences Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salem","family":"Aljaddua","sequence":"additional","affiliation":[{"name":"Department of surgery Jouf University Aljouf Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Alasiri","sequence":"additional","affiliation":[{"name":"Department of surgery Rijal Almaa General Hospital Rijal Almaa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Boukhari","sequence":"additional","affiliation":[{"name":"Department of surgery King Khalid University Abha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulmonem Ali","family":"Alhussain","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery King Fahad Hospital Hofuf, Ahsa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8392-2072","authenticated-orcid":false,"given":"Bipin","family":"Chaurasia","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Neurosurgery Clinic Birgunj Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3559-3307","authenticated-orcid":false,"given":"Saud Nayef","family":"Aldanyowi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Medical College King Faisal University Hofuf, Ahsa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000640"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-017-0450-z"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2021.102305"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000471"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5049.118517"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-020-01216-9"},{"key":"e_1_2_10_8_1","article-title":"Duloxetine Versus Other Anti\u2010depressive Agents for Depression","volume":"10","author":"Cipriani A.","year":"2012","journal-title":"Cochrane Database of Systematic Reviews (Online)"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2020.109785"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2015.01.003"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.14.030191.001251"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3344\/kjp.2020.33.1.40"},{"key":"e_1_2_10_13_1","unstructured":"Higgins J.P.T. 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