{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:39:56Z","timestamp":1792175996243,"version":"4.4.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T00:00:00Z","timestamp":1737244800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Cerebral amyloid angiopathy (CAA) is recognized as a major contributor to progressive cognitive decline and cerebral hemorrhages in the elderly population. Currently, there is a global shortage of safe and effective treatments for this condition. Bisdemethoxycurcumin (BDMC) has been demonstrated to exhibit pharmacological effects with anti\u2010A\u03b2 toxicity properties. Thus, the present study mainly focused on the potential therapeutic effects of BDMC on CAA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>The 30 male C57BL\/6 mice were subjected to chronic treatment with five vascular risk factors (lipopolysaccharide, social stress, streptozotocin, high\u2010cholesterol diet, and copper\u2010containing drinking water) for 35 weeks to establish a CAA mouse model. Of these, 15 CAA mice received oral administration of BDMC (50\u00a0mg\/kg) for two consecutive weeks as an intervention, while the remaining 15 CAA mice received an equal volume of physiological saline by gavage. The study observed the levels of A\u03b240 and proinflammatory factors in brain tissue and plasma, A\u03b2 deposition in cerebral blood vessels, microbleeds in brain tissue, expression of proteins related to the cGAS\/STING signaling pathway in brain tissue, as well as the contents of p\u2010RIPK\u20101, p\u2010RIPK\u20103, p\u2010MLKL, neuronal morphology, and learning and memory abilities in mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>The therapeutic administration of BDMC demonstrates a pronounced efficacy in alleviating A\u03b2 burden and cerebral microbleeding in CAA mice, concurrently enhancing learning and memory capabilities. Interestingly, BDMC may inhibits neuroinflammatory responses by reducing the expression of cGAS\/STING signaling pathway proteins and suppresses necroptosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our research findings demonstrate that BDMC exerts therapeutic effects in a mouse model of CAA established through chronic treatment involving five vascular risk factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70245","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T02:27:48Z","timestamp":1737340068000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Study on the Therapeutic Effects of Bisdemethoxycurcumin on a Cerebral Amyloid Angiopathy Mouse Model Established via Chronic Treatment With Five Vascular Risk Factors"],"prefix":"10.1002","volume":"15","author":[{"given":"Shudong","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Multi\u2010Omics Research Center for Brain Disorders, Hengyang Medical School University Of South China  Hengyang Hunan China"},{"name":"Clinical Research Center for Immune\u2010Related Encephalopathy In Hunan Province, Hengyang Medical School University Of South China  Hengyang Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghua","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Multi\u2010Omics Research Center for Brain Disorders, Hengyang Medical School University Of South China  Hengyang Hunan China"},{"name":"Clinical Research Center for Immune\u2010Related Encephalopathy In Hunan Province, Hengyang Medical School University Of South China  Hengyang Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Multi\u2010Omics Research Center for Brain Disorders, Hengyang Medical School University Of South China  Hengyang Hunan China"},{"name":"Department of Emergency, The First Affiliated Hospital, Hengyang Medical School University of South China  Hengyang Hunan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanwei","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Multi\u2010Omics Research Center for Brain Disorders, Hengyang Medical School University Of South China  Hengyang Hunan China"},{"name":"Clinical Research Center for Immune\u2010Related Encephalopathy In Hunan Province, Hengyang Medical School University Of South China  Hengyang Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Multi\u2010Omics Research Center for Brain Disorders, Hengyang Medical School University Of South China  Hengyang Hunan China"},{"name":"Clinical Research Center for Immune\u2010Related Encephalopathy In Hunan Province, Hengyang Medical School University Of South China  Hengyang Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Multi\u2010Omics Research Center for Brain Disorders, Hengyang Medical School University Of South China  Hengyang Hunan China"},{"name":"Clinical Research Center for Immune\u2010Related Encephalopathy In Hunan Province, Hengyang Medical School University Of South China  Hengyang Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guozhi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Multi\u2010Omics Research Center for Brain Disorders, Hengyang Medical School University Of South China  Hengyang Hunan China"},{"name":"Clinical Research Center for Immune\u2010Related Encephalopathy In Hunan Province, Hengyang Medical School University Of South China  Hengyang Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Multi\u2010Omics Research Center for Brain Disorders, Hengyang Medical School University Of South China  Hengyang Hunan China"},{"name":"Clinical Research Center for Immune\u2010Related Encephalopathy In Hunan Province, Hengyang Medical School University Of South China  Hengyang Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7711-9171","authenticated-orcid":false,"given":"Shuangxi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Multi\u2010Omics Research Center for Brain Disorders, Hengyang Medical School University Of South China  Hengyang Hunan China"},{"name":"Clinical Research Center for Immune\u2010Related Encephalopathy In Hunan Province, Hengyang Medical School University Of South China  Hengyang Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5137-9549","authenticated-orcid":false,"given":"Zijian","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Multi\u2010Omics Research Center for Brain Disorders, Hengyang Medical School University Of South China  Hengyang Hunan China"},{"name":"Clinical Research Center for Immune\u2010Related Encephalopathy In Hunan Province, Hengyang Medical School University Of South China  Hengyang Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat8657"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2014.03.005"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-019-01967-4"},{"key":"e_1_2_9_5_1","first-page":"00","article-title":"The ARRIVE Guidelines 2.0: Updated Guidelines for Reporting Animal Research","volume":"18","author":"Boutron I.","year":"2020","journal-title":"PLoS Biology"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2883"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx047"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.011955"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2021.102376"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00524-z"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2019.01.009"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23169237"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.02.016"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0281-2"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-020-00637-3"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02602-y"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22083869"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12366"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20170033"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00114-X"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/1747493020974464"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2013.155"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2019.100916"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2008.12.005"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20082874"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09491"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21041225"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2019.06.027"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10112903"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25795"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201949799"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20160607"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12787"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.123283"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.07.222"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27341"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-021-00448-5"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2013.00019"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.07.045"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2015.05.006"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.116"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1515\/tnsci-2020-0143"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.3c01067"},{"key":"e_1_2_9_44_1","first-page":"00","article-title":"Treatment of Radiation\u2010Induced Brain Injury With Bisdemethoxycurcumin","volume":"18","author":"Xie M.","year":"2023","journal-title":"Neural Regeneration Research"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1515\/tnsci-2020-0140"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1655"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2019.125700"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.70245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T08:50:45Z","timestamp":1738140645000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.70245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/brb3.70245"],"URL":"https:\/\/doi.org\/10.1002\/brb3.70245","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.70245\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70245\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70245\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70245\/v1\/decision1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-05-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70245"}}