{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:00:54Z","timestamp":1772118054780,"version":"3.50.1"},"reference-count":60,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prior research has been conducted to understand the connection between maternal physical health and its effects on children and adolescents. Much less research has focused on maternal mental health and gene\u2010environmental factors that influence children's and adolescent's development. This study investigated the risk factors and gene\u2010environment interactions in relation to maternal mental health and adolescent depression and cognition risk for suicide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The data and sample utilized in this research were obtained from The Future of Families and Child Wellbeing Study. The cohort comprises a total of 4898 children and their corresponding caregivers, of which 1829 had complete data and were used in this study. To account for missing data, the list wise deletion approach was employed for all analyses. The variables were tested using Likert scales and\/or other similar scales designed to specifically measure the variable. Hypotheses were tested with multiple regressions and bootstrapping. Multiple comparisons were controlled with the Benjamini Hochberg false discovery approach, and BH adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u2010values are reported with each statistically significant result.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The analyses revealed four significant relationships: (1) poverty status is a strong predictor of adolescent mental health, (2) toddler attachment is affected by maternal mental health but does not interact with maternal mental health to predict adolescent mental health, (3) maternal mental health affects suspected childhood sexual abuse associations with adolescent mental health, and (4) serotonin transporter alleles (SLC6A4) exert specific effects on adolescent mental health cognitions previously linked to suicide risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In summary, this study concludes that the experiential factors and genetic variation have interconnected influences on the mental well\u2010being of children and adolescents. Therefore, interventions aimed at addressing child trauma would be enhanced by integrating a component that specifically addresses the mental well\u2010being of mothers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70247","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T02:04:40Z","timestamp":1738807480000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Adolescent Depression and Cognition Risk for Suicide: An Investigation of Risk Factors and Gene Environment Interactions"],"prefix":"10.1002","volume":"15","author":[{"given":"Stefanie","family":"Pilkay","sequence":"first","affiliation":[{"name":"School of Social Work Syracuse University  Syracuse New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6575-8355","authenticated-orcid":false,"given":"Devorah","family":"Halevy","sequence":"additional","affiliation":[{"name":"Wurzweiler School of Social Work Yeshiva University  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Femia","sequence":"additional","affiliation":[{"name":"School of Social Work Syracuse University  Syracuse New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sage Malina","family":"Holland","sequence":"additional","affiliation":[{"name":"School of Social Work Syracuse University  Syracuse New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0272-4100","authenticated-orcid":false,"given":"Stephanie","family":"Heiland","sequence":"additional","affiliation":[{"name":"School of Social Work Syracuse University  Syracuse New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew M","family":"Carroll","sequence":"additional","affiliation":[{"name":"School of Social Work Syracuse University  Syracuse New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Nunes","sequence":"additional","affiliation":[{"name":"School of Social Work Syracuse University  Syracuse New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara","family":"Veerman","sequence":"additional","affiliation":[{"name":"School of Social Work Centenary University  Hackettstown New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leah","family":"Dudak","sequence":"additional","affiliation":[{"name":"School of Information Studies Syraucse University  Syracuse New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001270050026"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291718003823"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1037\/0003-066X.45.3.385"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/10503307.2018.1543977"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199912000-00010"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-8624.2009.01288.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10964-016-0548-5"},{"key":"e_1_2_8_10_1","unstructured":"CDC.Suicide data and statistics.2023.https:\/\/www.cdc.gov\/suicide\/suicide\u2010data\u2010statistics.html."},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.190603"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.01.002"},{"key":"e_1_2_8_13_1","first-page":"1","article-title":"\u201cPuberty Age Gap\u201d: New Method of Assessing Pubertal Timing and Its Association With Mental Health Problems","author":"Dehestani N.","year":"2023","journal-title":"Molecular Psychiatry"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003329170800456X"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes11111260"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jclp.21957"},{"issue":"1","key":"e_1_2_8_17_1","first-page":"169","article-title":"Depression and Suicidal Behavior in Adolescents","volume":"107","author":"Grossberg A.","year":"2023","journal-title":"Medical Clinics"},{"key":"e_1_2_8_18_1","volume-title":"Introduction to Mediation, Moderation, and Conditional Process Analysis: A Regression\u2010Based Approach","author":"Hayes A. 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