{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T07:57:40Z","timestamp":1777190260462,"version":"3.51.4"},"reference-count":67,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","award":["2017\u20101531"],"award-info":[{"award-number":["2017\u20101531"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010790","name":"Erasmus+","doi-asserted-by":"publisher","award":["2013\u20100040"],"award-info":[{"award-number":["2013\u20100040"]}],"id":[{"id":"10.13039\/501100010790","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010552","name":"Departament de Salut, Generalitat de Catalunya","doi-asserted-by":"publisher","award":["SLT008\/18\/00156"],"award-info":[{"award-number":["SLT008\/18\/00156"]}],"id":[{"id":"10.13039\/501100010552","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010434","name":"'la Caixa' Foundation","doi-asserted-by":"publisher","award":["LCF\/BQ\/DI17\/11620069"],"award-info":[{"award-number":["LCF\/BQ\/DI17\/11620069"]}],"id":[{"id":"10.13039\/100010434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["AC21_2\/00016"],"award-info":[{"award-number":["AC21_2\/00016"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI16\/00861"],"award-info":[{"award-number":["PI16\/00861"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The impact of ventriculomegaly (VM) on cortical development and brain functionality has been extensively explored in existing literature. VM has been associated with higher risks of attention\u2010deficit and hyperactivity disorders, as well as cognitive, language, and behavior deficits. Some studies have also shown a relationship between VM and cortical overgrowth, along with reduced cortical folding, both in fetuses and neonates. However, there is a lack of longitudinal studies that study this relationship from fetuses to neonates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We used a longitudinal dataset of 30 subjects (15 healthy controls and 15 subjects diagnosed with isolated non\u2010severe VM (INSVM)) with structural MRI acquired in and ex utero for each subject. We focused on the impact of fetal INSVM on cortical development from a longitudinal perspective, from the fetal to the neonatal stage. Particularly, we examined the relationship between ventricular enlargement and both volumetric features and a multifaceted set of cortical folding measures, including local gyrification, sulcal depth, curvature, and cortical thickness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>Our results show significant effects of isolated non\u2010severe VM (INSVM) compared to healthy controls, with reduced cortical thickness in specific brain regions such as the occipital, parietal, and frontal lobes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings align with existing literature, confirming the presence of alterations in cortical growth and folding in subjects with isolated non\u2010severe VM (INSVM) from the fetal to neonatal stage compared to controls.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70255","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T11:45:59Z","timestamp":1737373559000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Longitudinal Assessment of Abnormal Cortical Folding in Fetuses and Neonates With Isolated Non\u2010Severe Ventriculomegaly"],"prefix":"10.1002","volume":"15","author":[{"given":"Andrea","family":"Urru","sequence":"first","affiliation":[{"name":"BCN MedTech, Department of Information and Communication Technologies Universitat Pompeu Fabra  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oualid","family":"Benkarim","sequence":"additional","affiliation":[{"name":"McConnell Brain Imaging Centre Montreal Neurological Institute and Hospital, McGill University  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4729-7182","authenticated-orcid":false,"given":"Gerard","family":"Mart\u00ed\u2010Juan","sequence":"additional","affiliation":[{"name":"BCN MedTech, Department of Information and Communication Technologies Universitat Pompeu Fabra  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Hahner","sequence":"additional","affiliation":[{"name":"BCNatal Fetal Medicine Research Center (Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u) University of Barcelona  Barcelona Spain"},{"name":"Department of Surgery and Surgical Specializations, Faculty of Medicine and Health Sciences University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma","family":"Piella","sequence":"additional","affiliation":[{"name":"BCN MedTech, Department of Information and Communication Technologies Universitat Pompeu Fabra  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisenda","family":"Eixarch","sequence":"additional","affiliation":[{"name":"BCNatal Fetal Medicine Research Center (Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u) University of Barcelona  Barcelona Spain"},{"name":"Department of Surgery and Surgical Specializations, Faculty of Medicine and Health Sciences University of Barcelona  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) and Centre for Biomedical Research on Rare Diseases (CIBERER)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A.","family":"Gonz\u00e1lez Ballester","sequence":"additional","affiliation":[{"name":"BCN MedTech, Department of Information and Communication Technologies Universitat Pompeu Fabra  Barcelona Spain"},{"name":"ICREA  Barcelona 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