{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:03:03Z","timestamp":1772118183202,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071320"],"award-info":[{"award-number":["82071320"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8601022"],"award-info":[{"award-number":["8601022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>We aimed to explore the difference in choroidal vascular parameters using swept\u2010source optical coherence tomography (SS\u2010OCT) in patients with idiopathic intracranial hypertension (IIH) compared to controls. We also explored the ability of the choroidal parameters to reflect elevated intracranial pressure (ICP) in patients with IIH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This observational study recruited patients diagnosed with IIH and healthy controls. A lumbar puncture was performed for ICP measurement. All the participants underwent OCT examinations. The choroid was automatically segmented and imaged by the OCT tool. The parafoveal choroidal vascular volume (CVV) and choroidal vascular index (CVI) were calculated in 3\u00a0mm annulus and 6\u00a0mm annulus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 80 patients with IIH (34.67\u00a0\u00b1\u00a011.00\u00a0years; 37.50% males) and 92 controls (34.50\u00a0\u00b1\u00a012.08\u00a0years; 36.96% males) were included in the final analysis. Patients with IIH had higher BMI (&lt;\u00a00.001) and poor visual acuity (&lt;\u00a00.001) compared with controls. Patients with IIH demonstrated significantly lower parafovea CVI in both annuluses (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.003 for 3\u00a0mm annulus,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001 for 6\u00a0mm annulus) compared to controls. Mean parafovea CVI in both annuluses was significantly correlated with ICP level (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.014 for 3\u00a0mm annulus,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.015 for 6\u00a0mm annulus). The combination of CVV and CVI in a 6\u00a0mm annulus demonstrated the highest diagnostic value with a mean AUC of 0.818.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CVI may serve as a potential marker for identifying IIH and reflecting ICP changes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70258","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T09:36:59Z","timestamp":1736415419000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Decreased Choroidal Vascular Index in Idiopathic Intracranial Hypertension"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6021-739X","authenticated-orcid":false,"given":"Hang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0414-9932","authenticated-orcid":false,"given":"Le","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Neurology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William Robert","family":"Kwapong","sequence":"additional","affiliation":[{"name":"Department of Neurology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruishan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, West China Hospital Sichuan University  Chengdu 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