{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:43:40Z","timestamp":1790934220838,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Autism, a developmental\u2010neurodegenerative disorder, often manifests as social communication difficulties and has been correlated to oxidative stress in the brain. Vitamins C and gallic acid (GA) possess potent antioxidant properties, making them potential candidates for addressing autism\u2010related issues. This study examined the influence of vitamin C (Vit C) and GA on behavioral, motor, and cognitive performance, along with the assessment of brain oxidative markers, using an experimental model of autism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Fourteen female rats were divided into saline and valproic acid (VPA) groups, and mating with mature male rats generated offspring. VPA (500\u00a0mg\/kg) was injected intraperitoneally (i.p.) on gestational day (GD) 12.5. Male pups remained undisturbed for 29 days. On postnatal day (PND) 30, 48 male pups were randomly selected and administered daily injections of Vit C (30\u00a0mg\/kg, i.p.) or GA (30\u00a0mg\/kg, i.p.) for 4 weeks (PND 38\u201365). Behavioral assessments were conducted before and after treatment (PND 30\u201337 and 66\u201373). Animals were then anesthetized, and their brains were analyzed for oxidative stress markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Finding<\/jats:title>\n                    <jats:p>The prenatal VPA\u2010induced autism model increased nociceptive threshold, heightened anxiety\u2010like behaviors, impaired balance power, delayed spatial learning, elevated malondialdehyde, and decreased glutathione and catalase levels in the brains of the male offspring. Administration of Vit C and GA effectively mitigated these anomalies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Vit C and GA could potentially alleviate anxiety\u2010like behaviors, motor and cognitive deficits, and brain oxidative stress markers in a prenatal rat autism model. This underscores their viability as potential pharmacological interventions for treating autistic dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70262","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T01:41:24Z","timestamp":1738806084000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Vitamin C and Gallic Acid Ameliorate Motor Dysfunction, Cognitive Deficits, and Brain Oxidative Stress in a Valproic Acid\u2010Induced Model of Autism"],"prefix":"10.1002","volume":"15","author":[{"given":"Parnia","family":"Tarahomi","sequence":"first","affiliation":[{"name":"Research Center of Physiology Semnan University of Medical Sciences  Semnan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Arab","sequence":"additional","affiliation":[{"name":"Research Center of Physiology Semnan University of Medical Sciences  Semnan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Ali","family":"Seyedinia","sequence":"additional","affiliation":[{"name":"Research Center of Physiology Semnan University of Medical Sciences  Semnan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrnoush","family":"Rahmani","sequence":"additional","affiliation":[{"name":"Research Center of Physiology Semnan University of Medical Sciences  Semnan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Rashidy\u2010Pour","sequence":"additional","affiliation":[{"name":"Research Center of Physiology Semnan University of Medical Sciences  Semnan Iran"},{"name":"Department of Physiology, School of Medicine Semnan University of Medical Sciences  Semnan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas Ali","family":"Vafaei","sequence":"additional","affiliation":[{"name":"Research Center of Physiology Semnan University of Medical Sciences  Semnan Iran"},{"name":"Department of Physiology, School of Medicine Semnan University of Medical Sciences  Semnan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2262-735X","authenticated-orcid":false,"given":"Payman","family":"Raise\u2010Abdullahi","sequence":"additional","affiliation":[{"name":"Research Center of Physiology Semnan University of Medical Sciences  Semnan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2020.112867"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201018432\u20100"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.02.041"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0007114514003729"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","unstructured":"Alizadeh N. 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