{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:14:07Z","timestamp":1791893647319,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Sugar addiction, characterized by excessive cravings for high\u2010sugar foods, poses a significant health challenge in modern society. The parallels between sugar and drug addiction have attracted attention, prompting extensive research on the neurological mechanisms involved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This review summarizes recent research on sugar addiction and its impact on health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Finding<\/jats:title>\n                    <jats:p>High\u2010sugar consumption activates the brain's reward circuits\u2014a positive reinforcement mechanism\u2014including the dopamine and endorphin systems, which are associated with satisfaction and pleasure. Chronic exposure to high\u2010sugar foods may alter these systems, leading to heightened cravings and a dependence on sugar. Appetite is regulated by complex neural pathways, including those in the prefrontal cortex, amygdala, and hypothalamus. Therefore, dysfunction of these areas may lead to excessive sugar intake and impulsivity. Sugar addiction also negatively affects physical health, with high\u2010sugar intake strongly associated with obesity, diabetes, cardiovascular diseases, and other health problems. Sugar addiction can lead to weight gain and metabolic disorders, which in turn increase the risk of developing these diseases. Pharmacological and psychological interventions are the primary treatment for sugar addiction. Certain medications can reduce sugar cravings and dependence; however, their long\u2010term efficacy and side effects require further investigation. Cognitive behavioral therapy can also help individuals change their attitudes and behaviors toward sugar, thereby enhancing their self\u2010control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In summary, sugar addiction is an increasingly prevalent problem involving multiple aspects of the nervous system, behavior, and health. Further research on sugar addiction will enhance understanding, inform preventive and treatment measures, and elucidate the mechanisms underlying sugar addiction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70338","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T09:55:23Z","timestamp":1752486923000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Sugar Addiction: Neural Mechanisms and Health Implications"],"prefix":"10.1002","volume":"15","author":[{"given":"Di","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Geriatrics China\u2010Japan Union Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2383-9405","authenticated-orcid":false,"given":"Jiayu","family":"Qi","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering Changchun University of Technology  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuqiang","family":"Shi","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering Changchun University of Technology  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering Changchun University of Technology  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwu","family":"Li","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering Changchun University of Technology  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755\u20107682\u20103\u201024"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2008.01.008"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2007.04.019"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/72.5.1128"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.670430"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2016.71"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2008.204"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20100765\u20108510"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201003144"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2002.66"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1037\/pha0000019"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011\u20101050"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102013\u2010305112"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2019.109469"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12103155"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports\u20102017\u2010097971"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.149567"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0006\u20108993(01)02451\u20109"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2022.110654"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.114.086918"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9070653"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10030487"},{"key":"e_1_2_10_24_1","doi-asserted-by":"crossref","unstructured":"Onaolapo A. 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