{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:08:04Z","timestamp":1787789284443,"version":"build-2784847793"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["(No.20212BAB216023)"],"award-info":[{"award-number":["(No.20212BAB216023)"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The present study aimed to evaluate the predictive abilities of hematoma volume, perihematomal edema (PHE) volume, and total lesion (hematoma + PHE) volume for poor outcome in patients with intracerebral hemorrhage (ICH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients admitted to our department between January 2015 and March 2023 were retrospectively enrolled according to the inclusion criteria and exclusion criteria. Demographic characteristics, clinical information, laboratory examinations, and imaging data were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 510 patients with initial computerized tomography (CT) scan (342 [67.1%] male, median age = 62\u2009years); 142 patients had CT scans at admission and 72 h post ICH, and 350 patients had CT scans at admission and 5\u20139 days after onset. Multivariate logistic regression analysis revealed that absolute hematoma, absolute PHE, and absolute total lesion at admission; absolute hematoma and absolute total lesion at 72 h after onset; absolute hematoma, absolute PHE, and absolute total lesion at 5\u20139 days post ICH were independently related to poor outcome (<jats:italic>p<\/jats:italic> &lt; 0.05). Furthermore, receiver operating characteristic curves demonstrated that the total volume of hematoma and PHE at 5\u20139 days post ICH was a better indicator to predict poor outcome, compared to other risk factors in patients with ICH (area under curve = 0.778, 95%CI: 0.729\u20130.826).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The total volume of hematoma and PHE at 5\u20139 days after onset had the highest ability in predicting poor outcome in patients with ICH.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.70340","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T06:34:57Z","timestamp":1739860497000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Hematoma, Perihematomal Edema, and Total Lesion Predict Outcome in Patients With Intracerebral Hemorrhage"],"prefix":"10.1002","volume":"15","author":[{"given":"Qin","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang China"},{"name":"Institute of Neurology, Jiangxi Academy of Clinical Medical Science, The First Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang China"},{"name":"Rare Disease Center, The First Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang China"},{"name":"Key Laboratory of Rare Neurological Diseases of Jiangxi Provincial Health Commission, Jiangxi Medical College Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang 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