{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T08:24:54Z","timestamp":1785399894341,"version":"3.56.0"},"reference-count":73,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471543"],"award-info":[{"award-number":["82471543"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Repetitive transcranial magnetic stimulation (rTMS) represents a potential clinical tool in treating bipolar disorder (BD). However, the intervention of rTMS combined with pharmacotherapy on the plasma fatty acids (FAs) in patients with bipolar depression has not been reported yet.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>In this study, we assessed the clinical symptoms and evaluated plasma FAs from 30 inpatients with bipolar depression at baseline phase (BD group), after 2 weeks of treatment with rTMS combined with quetiapine and mood stabilizer (BD\u20102w group), and 32 healthy controls (HCs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Finding<\/jats:title>\n                    <jats:p>We found that acetic acid, propionic acid, isovaleric acid, isobutyric acid, and valeric acid, as well as levels of total short\u2010chain fatty acids (SCFAs), were decreased in both BD and BD\u20102w groups, and levels of several medium\u2010 and long\u2010chain fatty acids (MLCFAs) were altered in BD when compared with HC. Moreover, 2 weeks of treatment increased the levels of various MLCFAs. Finally, we developed combinational FAs panels that could distinguish BD from HC (area under the curve [AUC] = 0.961), BD\u20102w from HC (AUC = 0.978), and BD from BD\u20102w (AUC = 0.891) effectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings might provide a basis for developing diagnostic methods and reveal the potential relationship between bipolar depression and plasma FAs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70341","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:51:10Z","timestamp":1740012670000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Alternations of Plasma Fatty Acids in Patients With Bipolar Depression Under Acute Treatment of rTMS Combined With Quetiapine and Mood Stabilizer"],"prefix":"10.1002","volume":"15","author":[{"given":"Huan","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Psychiatry Chang'an Hospital  Xi'an China"},{"name":"Department of Psychiatry Xijing Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue\u2010jun","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Chang'an Hospital  Xi'an China"},{"name":"Mental Diseases Prevention and Treatment Institute of Chinese PLA No. 988 Hospital of Joint Logistic Support Force  Jiaozuo Henan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010ting","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Chang'an Hospital  Xi'an China"},{"name":"Department of Psychiatry Xijing Hospital  Xi'an 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