{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:42:39Z","timestamp":1792176159608,"version":"4.4.0"},"reference-count":66,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T00:00:00Z","timestamp":1742688000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Primary sensory processing is atypical in patients with autism spectrum disorder (ASD) and affects daily functioning. However, the functional connectivity (FC) patterns of primary networks in ASD have not been systematically investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Primary networks were defined as four regions of interest (ROIs) in each brain hemisphere. We analyzed ROI\u2010wise FC in 105 individuals with ASD and 132 typically developing (TD) participants from Autism Brain Imaging Data Exchange I. We calculated the correlation between abnormal FC and clinical scores. Additionally, data from 53 individuals with ASD from our laboratory's two\u2010site dataset were used to validate the results and assess the effects of sex and age on FC consistency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Regarding the ROI\u2010wise connectivity, significant group differences in FC emerged in several regional pairs, particularly in the primary auditory and somatosensory regions. Abnormal brain regions correlated with clinical symptoms. As age increased, abnormal FC had an initial fast and then slowing development trend, and the abnormal FC in females was higher than that in males. The two\u2010site dataset results were consistent with those of the multisite dataset in assessing the influence of age and sex on FC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Abnormal FC exists in the primary sensory cortex of patients with ASD, which correlates with clinical outcomes and may cause impairments in advanced cognitive functions. In addition, the primary sensory cortex of patients with ASD may undergo excessive growth in the early stages and demonstrate imbalanced development according to sex. These findings may help identify new biomarkers for ASD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70363","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T02:52:48Z","timestamp":1742784768000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Abnormal Functional Connectivity of the Primary Sensory Network in Autism Spectrum Disorder: Sex Differences, Early Overdevelopment, and Clinical Significance"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8791-7183","authenticated-orcid":false,"given":"Yanan","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Mental Health and Psychological Sciences Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Zhou","sequence":"additional","affiliation":[{"name":"First Clinical Medical College Anhui 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