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The aim of this study was to investigate clinical differences between clusters created according to neurocognitive performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study combined data sets from three previously published studies. A total of 135 outpatients diagnosed with OCD, and 106 healthy controls (HCs) were evaluated using the 17\u2010Item Hamilton Depression Rating Scale\u00a0(HDRS\u201017) and a comprehensive neuropsychological battery. Patients were also administered the Yale\u2010Brown Obsessive Compulsive Scale (Y\u2010BOCS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two neurocognitive subgroups were identified by\n                      <jats:italic>k<\/jats:italic>\n                      \u2010means cluster analysis: globally impaired (GI,\n                      <jats:italic>n<\/jats:italic>\n                      = 42) and cognitively intact (CI,\n                      <jats:italic>n<\/jats:italic>\n                      = 93). The GI subgroup performed worse than the HC and CI groups on all neurocognitive tests. There was no difference between the CI group and HC in any cognitive domains. Compulsive symptom severity [\n                      <jats:italic>t<\/jats:italic>\n                      (133) = \u22122.45,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.015], Y\u2010BOCS total score [\n                      <jats:italic>t<\/jats:italic>\n                      (133) = \u22122.09,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.038], and age of onset were higher in the GI group than in the CI group [\n                      <jats:italic>t<\/jats:italic>\n                      (132) = \u22124.24,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001]. Years of education were higher in the CI and HC groups than in the GI group [\n                      <jats:italic>F<\/jats:italic>\n                      (238) = 35.27,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001]. There was no difference in symptom profile between the CI and GI groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The identified cognitive clusters may indicate subtypes with different neurobiological bases. A better dissection of the cognitive structure of OCD could potentially facilitate genetic and neuroimaging studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70375","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T08:31:08Z","timestamp":1741854668000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Characteristics of Cognitive Subgroups of Obsessive Compulsive Disorder"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8953-1171","authenticated-orcid":false,"given":"Emre","family":"M\u0131s\u0131r","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine Baskent University Ankara Turkey"},{"name":"Department of Interdiciplinary Neuroscience, Graduate School of Health Sciences Ankara University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u015fit","family":"T\u00fckel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine \u0130stanbul University \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berna Binnur","family":"Akdede","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine Dokuz Eyl\u00fcl University \u0130zmir Turkey"},{"name":"Department of Neurosciences, Health Sciences Institute Dokuz Eyl\u00fcl University \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emre","family":"Bora","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine Dokuz Eyl\u00fcl University \u0130zmir Turkey"},{"name":"Department of Neurosciences, Health Sciences Institute Dokuz Eyl\u00fcl University \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2013.09.004"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2018.09.003"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2015.04.025"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199306000-00010"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobeha.2018.01.003"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.154"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2017.1567"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2015.01798"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.10.018"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.08020320"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291720001634"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2016.04.002"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2022.12.005"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22785"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291714000439"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065\u2010021\u201009525\u20100"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2015.17.1\/bcuthbert"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.13040574"},{"key":"e_1_2_11_20_1","unstructured":"Delis D. 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