{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:03:02Z","timestamp":1772118182484,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the effects of craniocervical atherosclerotic stenosis (AS) on the occurrence of neurologic deterioration (ND) in patients with small vessel occlusion (SVO) stroke and the outcomes of patients with SVO stroke with ND (SVO\u2010ND).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with SVO stroke were consecutively enrolled. AS was defined as a craniocervical artery with \u2265 50% stenosis caused by atherosclerosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The presence of craniocervical AS (adjusted odds ratio [aOR] = 2.57, 95% confidence interval [CI] = 1.12\u20135.89,\n                      <jats:italic>p =<\/jats:italic>\n                      0.026) and the number of craniocervical AS (aOR = 2.08, 95% CI = 1.25\u20133.44,\n                      <jats:italic>p =<\/jats:italic>\n                      0.005) were associated with the occurrence of ND in patients with SVO stroke. Compared with SVO stroke patients with no craniocervical AS, the risk of ND increased in those with multiple AS (aOR = 6.47, 95% CI = 1.73\u201324.05,\n                      <jats:italic>p =<\/jats:italic>\n                      0.005). The risk of poor outcomes increased in SVO\u2010ND patients with multiple AS than SVO\u2010ND patients with no AS (aOR = 47.75, 95% CI = 1.66\u2013375.17,\n                      <jats:italic>p =<\/jats:italic>\n                      0.024).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The presence and the number of craniocervical AS are associated with ND in SVO stroke patients and with poststroke disability in SVO\u2010ND patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70391","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T22:46:14Z","timestamp":1741733174000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Craniocervical Atherosclerotic Stenosis on the Occurrence of Neurologic Deterioration in Patients With Small Vessel Occlusion Stroke and Their Clinical Outcomes"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0429-266X","authenticated-orcid":false,"given":"Wei","family":"Han","sequence":"first","affiliation":[{"name":"Department of Neurology Affiliated Hospital of Jiangsu University  Zhenjiang Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurology Affiliated Hospital of Jiangsu University  Zhenjiang Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YuanWei","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Radiology Affiliated Hospital of Jiangsu University  Zhenjiang Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pacifique","family":"Sibomana","sequence":"additional","affiliation":[{"name":"Kibagabaga Level II Teaching Hospital  Kigali Rwanda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology Affiliated Hospital of Jiangsu University  Zhenjiang Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurology Affiliated Hospital of Jiangsu University  Zhenjiang Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.1.35"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105494"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567202619666220214105208"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.6.1208"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.15.8.774"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.1073267"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1667141"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000447130"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.6.1741S"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.007466"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000375"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2014.16.3.161"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.004099"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.03.018"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.672741"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185314"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.09.024"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2004.01.031"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0221597"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.22.6.711"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000113732"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010603"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.670737"},{"issue":"4","key":"e_1_2_11_25_1","first-page":"643","article-title":"A Standardized Method for Measuring Intracranial Arterial Stenosis","volume":"21","author":"Samuels O. 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