{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:32:29Z","timestamp":1786977149172,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cerebral venous thrombosis (CVT) has various risk factors, including contraception, pregnancy, neoplasia, and thrombophilia. Nitrous oxide (N\u2082O), historically used as an anesthetic and more recently as a recreational drug, has been associated with neurological complications such as myeloneuropathy and thromboembolic events. Here, we report two cases of CVT associated with N\u2082O use and provide a review of the literature on this association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We describe two local cases of CVT associated with N\n                      <jats:sub>2<\/jats:sub>\n                      O use and 10 additional cases identified by literature review.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 12 patients, seven had co\u2010existing CVT risk factors. Most patients reported chronic N\n                      <jats:sub>2<\/jats:sub>\n                      O use. Hyperhomocysteinemia was reported in nine patients. Management included anticoagulation, vitamin supplementation, cessation of N\u2082O use, and support for addiction or psychiatric care. The outcome was generally favorable, although one local case experienced CVT recurrence following a relapse in N\u2082O use.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These cases highlight an emerging association between CVT and N\u2082O use. Prompt recognition of this link is critical to recommend cessation of N\u2082O use, alongside anticoagulation therapy and consideration of vitamin supplementation to prevent complications and recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70394","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T03:55:22Z","timestamp":1740974122000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cerebral Venous Thrombosis and Nitrous Oxide Intoxication: Report of Two Cases and Review of the Literature"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9359-0471","authenticated-orcid":false,"given":"Diana","family":"Doukhi","sequence":"first","affiliation":[{"name":"Neurology Department H\u00f4pital Lariboisi\u00e8re, APHP  Paris France"},{"name":"FHU NeuroVasc  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6509-8964","authenticated-orcid":false,"given":"Virginie","family":"Siguret","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"INSERM, U1140  Paris France"},{"name":"Hematology Laboratory Department H\u00f4pital Lariboisi\u00e8re, APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6320-2887","authenticated-orcid":false,"given":"Dominique","family":"Vodovar","sequence":"additional","affiliation":[{"name":"M\u00e9decine Intensive R\u00e9animation, H\u00f4pital Charles Nicolle  Rouen France"},{"name":"U.F.R. de m\u00e9decine Universit\u00e9 Rouen Normandie  Rouen France"},{"name":"INSERM, U1096 Universit\u00e9 Rouen Normandie  Rouen 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