{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:26:55Z","timestamp":1791473215383,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n We used a two\u2010sample mendelian randomization (MR) method to comprehensively investigate the causality of metabolic syndrome (MetS) or its components, including MetS, triglyceride (TG), high\u2010density lipoprotein cholesterol (HDL\u2010C), low\u2010density lipoprotein cholesterol (LDL\u2010C), fasting blood glucose (FBG), waist circumference (WC), and hypertension (HP), with cerebral aneurysm including nonruptured and ruptured aneurysmal subarachnoid hemorrhage (SAH).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n By leveraging large\u2010scale genome\u2010wide association study (GWAS) summary statistics of MetS or its components and cerebral aneurysm (nonruptured and SAH) from European, MR, reverse\u2010direction MR, and sensitivity analysis were utilized to quantify the genetic correlations and causal relationships. In addition, we adjusted for multiple comparisons using the false discovery rate (FDR) correction.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Two\u2010sample MR analysis showed that HP was a risk factor for cerebral aneurysm (nonruptured and SAH) with odds ratio (OR) of 58.959 (95% confidence interval [95% CI] = 12.073\u2013287.920,\n p\u00a0<\/jats:italic>\n <\u00a00.001,\n q<\/jats:italic>\n \u00a0<\u00a00.001), and 32.290 (95% CI = 5.615\u2013185.671,\n p\u00a0<\/jats:italic>\n <\u00a00.001,\n q\u00a0<\/jats:italic>\n <\u00a00.001), respectively. HDL\u2010C (OR = 0.836, 95% CI = 0.728\u20130.960,\n p<\/jats:italic>\n = 0.011,\n q<\/jats:italic>\n = 0.039) and FBG (OR = 0.626, 95% CI = 0.426\u20130.919,\n p<\/jats:italic>\n = 0.017,\n q<\/jats:italic>\n = 0.039) were negatively correlated with cerebral aneurysm (nonruptured). The HDL\u2010C result was inconsistent after adjusting for TG and LDL\u2010C by multivariable MR analysis. In reverse MR analysis, we found that there was no statistical causal association between cerebral aneurysm (nonruptured) and MetS or its components. Genetic liability to cerebral aneurysm (SAH) was inversely associated with HDL\u2010C and FBG but was not associated with others, however, sensitivity analysis showed that few instrumental variables made a big difference.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Genetically determined elevated FBG level reduces the risk of cerebral aneurysm (nonruptured). However, hypertension increases the risk of cerebral aneurysm (nonruptured and SAH).<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/brb3.70396","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T03:25:55Z","timestamp":1741749955000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Two\u2010Sample Bidirectional Mendelian Randomization Study With Causal Association Between Metabolic Syndrome and Cerebral Aneurysm"],"prefix":"10.1002","volume":"15","author":[{"given":"Yu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4330-8166","authenticated-orcid":false,"given":"Kai","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan 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