{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:32:56Z","timestamp":1780921976633,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T00:00:00Z","timestamp":1492646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004595","name":"Universiti Sains Malaysia","doi-asserted-by":"publisher","award":["304\/PPSK\/61312093"],"award-info":[{"award-number":["304\/PPSK\/61312093"]}],"id":[{"id":"10.13039\/501100004595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004595","name":"Universiti Sains Malaysia","doi-asserted-by":"publisher","award":["1001\/PPSK\/812139"],"award-info":[{"award-number":["1001\/PPSK\/812139"]}],"id":[{"id":"10.13039\/501100004595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2017,6]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>REM<\/jats:styled-content> sleep deprivation is associated with impairment in learning and memory, and nicotine treatment has been shown to attenuate this effect. Recent studies have demonstrated the importance of DREAM<\/jats:styled-content> protein in learning and memory processes. This study investigates the association of DREAM<\/jats:styled-content> protein in REM<\/jats:styled-content> sleep\u2010deprived rats hippocampus upon nicotine treatment.<\/jats:p><\/jats:sec>Methods<\/jats:title>Male Sprague Dawley rats were subjected to normal condition, REM<\/jats:styled-content> sleep deprivation and control wide platform condition for 72\u00a0hr. During this procedure, saline or nicotine (1\u00a0mg\/kg) was given subcutaneously twice a day. Then, Morris water maze (MWM<\/jats:styled-content>) test was used to assess learning and memory performance of the rats. The rats were sacrificed and the brain was harvested for immunohistochemistry and Western blot analysis.<\/jats:p><\/jats:sec>Results<\/jats:title>MWM<\/jats:styled-content> test found that REM<\/jats:styled-content> sleep deprivation significantly impaired learning and memory performance without defect in locomotor function associated with a significant increase in hippocampus DREAM<\/jats:styled-content> protein expression in CA<\/jats:styled-content>1, CA<\/jats:styled-content>2, CA<\/jats:styled-content>3, and DG<\/jats:styled-content> regions and the mean relative level of DREAM<\/jats:styled-content> protein compared to other experimental groups. Treatment with acute nicotine significantly prevented these effects and decreased expression of DREAM<\/jats:styled-content> protein in all the hippocampus regions but only slightly reduce the mean relative level of DREAM<\/jats:styled-content> protein.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>This study suggests that changes in DREAM<\/jats:styled-content> protein expression in CA<\/jats:styled-content>1, CA<\/jats:styled-content>2, CA<\/jats:styled-content>3, and DG<\/jats:styled-content> regions of rat's hippocampus and mean relative level of DREAM<\/jats:styled-content> protein may involve in the mechanism of nicotine treatment\u2010prevented REM<\/jats:styled-content> sleep deprivation\u2010induced learning and memory impairment in rats.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.704","type":"journal-article","created":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T07:33:09Z","timestamp":1492673589000},"source":"Crossref","is-referenced-by-count":9,"title":["Nicotine\u2010prevented learning and memory impairment in REM<\/scp> sleep\u2010deprived rat is modulated by DREAM<\/scp> protein in the hippocampus"],"prefix":"10.1002","volume":"7","author":[{"given":"Norlinda","family":"Abd Rashid","sequence":"first","affiliation":[{"name":"BRAINetwork Centre for Neurocognitive Sciences School of Health Sciences University Sains Malaysia Kubang Kerian Kelantan Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermizi","family":"Hapidin","sequence":"additional","affiliation":[{"name":"School of Health Sciences University Sains Malaysia Kubang Kerian Kelantan Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasmah","family":"Abdullah","sequence":"additional","affiliation":[{"name":"School of Health Sciences University Sains Malaysia Kubang Kerian Kelantan Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zalina","family":"Ismail","sequence":"additional","affiliation":[{"name":"BRAINetwork Centre for Neurocognitive Sciences School of Health Sciences University Sains Malaysia Kubang Kerian Kelantan Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6828-1908","authenticated-orcid":false,"given":"Idris","family":"Long","sequence":"additional","affiliation":[{"name":"BRAINetwork Centre for Neurocognitive Sciences School of Health Sciences University Sains Malaysia Kubang Kerian Kelantan Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(00)00194-X"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20716"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.05.025"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2005.12.005"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20806"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2011.02.006"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.04.069"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2008.11.056"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20717"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705454104"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.80504"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/383713a0"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.115287"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(02)01704-6"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2015_369"},{"key":"e_1_2_8_17_1","first-page":"1","article-title":"Modulation of formalin\u2010induced Fos\u2010like immunoreactivity in the spinal cord by swim stress\u2010induced analgesia, morphine and ketamine","volume":"6","author":"Hayati A. 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