{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:34:53Z","timestamp":1786977293392,"version":"build-2736575974"},"reference-count":129,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Patients undergoing open\u2010heart surgery often face significant challenges in postoperative cognitive dysfunction (POCD). There has been growing interest in understanding how anesthesia medications, such as dexmedetomidine (DEX) and midazolam, impact cognitive function in these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This comprehensive review aims to detail the effect of DEX and midazolam on cognitive outcomes following open\u2010heart surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>Midazolam, a highly selective and commonly used benzodiazepine for preoperative anxiolytics and sedation has been associated with POCD. However, evidence regarding its impact on cognitive function is vague; some studies suggest a potential link between midazolam administration and cognitive impairment, while others report no effect or even an improvement in cognitive abilities. DEX is a potential neuroprotective agent in cardiac surgery. The effects of DEX on cognitive function, including a reduction in POCD incidence and severity, have been reported in several studies. It modulates the inflammatory responses, attenuates oxidative stress, and preserves cerebral perfusion. Although DEX and midazolam show promising results, their effects on cognitive function following open\u2010heart surgery are yet to be elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Various factors, including patient characteristics, perioperative management, and surgical procedures, may influence these outcomes, highlighting the need for further research to better understand the roles of these agents in cognitive function following open\u2010heart surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70421","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T03:40:59Z","timestamp":1744170059000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of Midazolam and Dexmedetomidine on Cognitive Dysfunction Following Open\u2010Heart Surgery: A Comprehensive Review"],"prefix":"10.1002","volume":"15","author":[{"given":"Masoomeh","family":"Tabari","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Moradi","sequence":"additional","affiliation":[{"name":"Clinical Research Development Unit, Ghaem Hospital Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Orthopedic Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Golbon Asalforoush","family":"Rezaieh","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8562-360X","authenticated-orcid":false,"given":"Malihe","family":"Aghasizadeh","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Vascular and Endovascular Surgery Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/2348-0548.124841"},{"key":"e_1_2_10_3_1","first-page":"53","volume-title":"Systemic Inflammatory Response and Cardiopulmonary Bypass. Essentials of Operative Cardiac Surgery","author":"Akar A. R.","year":"2023"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2017.01.001"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/JMDH.S431168"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/rapm-2021-102989"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/sja.SJA_303_17"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11040706"},{"key":"e_1_2_10_9_1","first-page":"7","article-title":"Analgesia and Sedation in Hospitalized Children","author":"Beckman E. J.","year":"2017","journal-title":"PedSAP Book 3: Sedation and Analgesia"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000968"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002194"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2021.106163"},{"issue":"3","key":"e_1_2_10_13_1","article-title":"From Acute to Chronic Postsurgical Pain: The Significance of the Acute Pain Response","volume":"65","author":"Blichfeldt\u2010Eckhardt M. R","year":"2018","journal-title":"Danish Medical Journal"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40140-019-00343-y"},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","unstructured":"Bond A. andM.Lader.2016.Benzodiazepines: A Discussion of Pharmacokinetic and Pharmacodynamic Effects. The SAGE Handbook of Drug & Alcohol Studies Volume 2 SAGE Publications Ltd: 162\u2010176.","DOI":"10.4135\/9781473922143.n11"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.4274\/TJAR.2024.231331"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.12730"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-018-0873-z"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01641"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aan.2022.06.003"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9185.150525"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2022.111030"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.4037\/aacnacc2017948"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0267659112470693"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.05.009"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.13667"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-021-04307-5"},{"key":"e_1_2_10_28_1","doi-asserted-by":"crossref","unstructured":"Erol M. K.2020.The effect of midazolam on delirium in patients undergoing coronary artery bypass surgery.","DOI":"10.5455\/annalsmedres.2019.12.898"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-023-02315-6"},{"issue":"2","key":"e_1_2_10_30_1","first-page":"118","article-title":"Cerebrovascular Events After Cardiovascular Surgery: Diagnosis, Management and Prevention Strategies","volume":"20","author":"Ferrante M.","year":"2023","journal-title":"Kardiochirurgia i Torakochirurgia Polska\/Polish Journal of Thoracic and Cardiovascular Surgery"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e318273f37e"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-024-04726-7"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-42974-0.00004-5"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.914435"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tacc.2018.04.002"},{"issue":"6","key":"e_1_2_10_36_1","first-page":"4685","article-title":"Effects of Dexmedetomidine on Postoperative Cognitive Function in Patients Undergoing Coronary Artery Bypass Grafting","volume":"16","author":"Gong Z.","year":"2018","journal-title":"Experimental and Therapeutic Medicine"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-015-9618-4"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aei062"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2020.05.005"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000220035.82989.79"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2008.01.012"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.2217\/pme-2019-0003"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1280013"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2016.12.010"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14905"},{"issue":"2","key":"e_1_2_10_46_1","first-page":"90","article-title":"Haemodynamic Monitoring in Acute Heart Failure \u2013 What You Need to Know","volume":"18","author":"Jasi\u0144ska\u2010Gniadzik K.","year":"2022","journal-title":"Advances in Interventional Cardiology\/Post\u0119py w Kardiologii Interwencyjnej"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012187"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001634"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.000936"},{"key":"e_1_2_10_50_1","first-page":"99","volume-title":"Frontiers in Clinical Drug Research\u2010CNS and Neurological Disorder","author":"Jin Z.","year":"2020"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2017.11.028"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.4103\/aca.ACA_139_19"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.4103\/aca.ACA_138_19"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.7326\/M16-0652"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3458.2008.00043.x"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S133896"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14511"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1177\/1559325820902345"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2022.101605"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.811954"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-021-01736-z"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fmre.2023.02.007"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.843069"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.4137\/JEN.S33444"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2020.02.035"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1097\/ANA.0000000000000554"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2019.110791"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001588"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2021.02.048"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2015-307962"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aev226"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-76382008000200015"},{"issue":"1","key":"e_1_2_10_73_1","first-page":"17","article-title":"The Effect of Continuous Propofol Versus Dexmedetomidine Infusion on Regional Cerebral Tissue Oxygen Saturation During Cardiopulmonary Bypass","volume":"26","author":"Metry A. A.","year":"2019","journal-title":"Romanian Journal of Anaesthesia and Intensive Care"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40140-020-00377-7"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2020.10.041"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph182312747"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077637"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.789796"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-015-4069-9"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12234"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.115.068601"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11040511"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.52965\/001c.24514"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.19082\/3768"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.3390\/fi16110424"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1177\/1089253215626728"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/370612"},{"key":"e_1_2_10_88_1","doi-asserted-by":"crossref","unstructured":"Perkowski S. Z. andM. A.Oyama.2024.Pathophysiology and anesthetic management of patients with cardiovascular disease. Veterinary Anesthesia and Analgesia: The Sixth Edition of Lumb and Jones: 680\u2010696.","DOI":"10.1002\/9781119830306.ch36"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-019-1160-7"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-9891-3_4"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2020.03.054"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12055-019-00909-9"},{"issue":"4","key":"e_1_2_10_93_1","first-page":"182","article-title":"Effect of Preoperative Dexmedetomidine on Prevalence of Postoperative Cognitive Dysfunction in Elderly Patients Candidate for Orthopedic Surgery Under General Anesthesia","volume":"6","author":"Pournajafian A.","year":"2020","journal-title":"Archives of Anesthesiology and Critical Care"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.5812\/aapm.116957"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1177\/2632352419895527"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000004202"},{"issue":"2","key":"e_1_2_10_97_1","first-page":"67","article-title":"Comparison Between the Effects of Dexmedetomidine and Midazolam on Postoperative Cognitive Impairment After Coronary Artery Bypasses Graft Surgery: A Randomized Clinical Trial","volume":"14","author":"Rajaei M.","year":"2019","journal-title":"Journal of Tehran University Heart Center"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1750"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2016.09.008"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11010072"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.36518\/2689-0216.1525"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11192954"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00752"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00752"},{"issue":"3","key":"e_1_2_10_105_1","article-title":"Revolutionizing Cardiac Anesthesia: A Comprehensive Review of Contemporary Approaches outside the Operating Room","volume":"16","author":"Samy N. K. D.","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahjo.2023.100277"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005196"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X18789273"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2012.03.008"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.35.4.1279"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108332"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-809915-5.00004-8"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12041610"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2011.07008.x"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15469"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1111\/nicc.13001"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.884907"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-024-02453-5"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40708-020-00116-y"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00019.2023"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.2c00173"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1201\/9780429186639-6"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2018.06.045"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.5406"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2023.08.147"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2015.06.009"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10102378"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-014-1857-z"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.549516"},{"issue":"3","key":"e_1_2_10_130_1","first-page":"290","article-title":"Research Progress of Postoperative Cognitive Dysfunction in Cardiac Surgery Under Cardiopulmonary Bypass","volume":"10","author":"Zhuang Y. M.","year":"2023","journal-title":"Ibrain"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.70421","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T08:43:29Z","timestamp":1759135409000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.70421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":129,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/brb3.70421"],"URL":"https:\/\/doi.org\/10.1002\/brb3.70421","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.70421\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70421\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70421\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70421\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70421\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70421\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70421\/v2\/review2","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2024-11-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70421"}}