{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:11:47Z","timestamp":1787508707203,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82003730"],"award-info":[{"award-number":["82003730"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The exact nature of the link between breast cancer and meningiomas is unknown, although observational studies have shown a correlation between the two. Using a two\u2010sample Mendelian randomization (MR) strategy, we aimed to investigate the effect of breast cancer on meningiomas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Three sets of genetic instruments were utilized in this study based on publicly available genetic summary data. For breast cancer, we selected 62 strongly associated SNPs; separate datasets were curated for HER2\u2010positive and HER2\u2010negative subtypes. MR analyses included outlier testing, MR\u2010Egger regression, MR\u2010PRESSO, weighted median, and inverse variance weighted approaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The inverse variance weighted analysis demonstrated significant evidence for breast cancer's effect on meningioma risk (OR = 1.213, 95% CI = 1.054\u20131.396,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.007), supported by MR\u2010Egger (OR = 1.456, 95% CI = 1.066\u20131.988,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.021) though not by the weighted median method (OR = 1.095, 95% CI = 0.914\u20131.311,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.326). Inverse variance weighting specifically revealed a significant association between HER2\u2010positive breast cancer and meningioma incidence (OR = 1.203, 95% CI = 1.048\u20131.381,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.009). Furthermore, breast cancer risk was associated with an increased incidence of malignant meningiomas (OR = 1.64, 95% CI = 1.12\u20132.40,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.011).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This represents the first MR study investigating the causal relationship between breast cancer and meningiomas. Our findings support the hypothesis that breast cancer may increase meningioma risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70422","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T04:35:20Z","timestamp":1741926920000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Breast Cancer and Meningioma Risk: A Mendelian Randomization Study"],"prefix":"10.1002","volume":"15","author":[{"given":"Jian\u2010Wei","family":"Huang","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery, The Third Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound, The Third Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Qing","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Fifth Affiliated Hospital Sun Yat\u2010Sen University  Zhuhai Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Yong","family":"He","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, The Third Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5165-0391","authenticated-orcid":false,"given":"Shuang\u2010Qi","family":"Gao","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, The Third Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Guo","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, The Third Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuchi.2014.05.006"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0344\u20100338(11)80326\u20102"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(19861001)58:7<1537::aid\u2010cncr2820580726>3.0.co;2\u2010p"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3493"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103592"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.Epi\u201013\u20101041"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1151837"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.18620"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010023\u201004874\u2010x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.18898"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1992.00530310101020"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075\u2010023\u201003115\u20106"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nor081"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019606\u2010200109000\u201000001"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201005473\u20108"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010023\u201005408\u20107"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.123.029623"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.08.047"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1042567"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0967\u20105868(02)00305\u20103"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2020.03.203"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9030319"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.05.023"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148\u2010023\u201001476\u2010y"},{"issue":"4","key":"e_1_2_10_26_1","first-page":"233","article-title":"Steroid Receptors in the Central Nervous System. 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