{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:46:34Z","timestamp":1775893594979,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To investigate the relationship between soluble platelet\u2010derived growth factor \u03b2 receptor (sPDGFR\u03b2) in cerebrospinal fluid (CSF) and Alzheimer's disease (AD) biomarkers, to determine whether high CSF sPDGGFR\u03b2 is a potential risk factor for postoperative delirium (POD), and to evaluate its predictive effect, so as to provide reference for clinical prevention and treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>CSF samples were collected preoperatively from cognitively normal participants aged 50\u201390 years undergoing knee\/hip replacement surgery under spinal\u2010epidural anesthesia. The concentrations of sPDGFR\u03b2, \u03b2\u2010amyloid 42 (A\u03b242), total tau protein (Ttau), and phosphorylated tau protein (Ptau) in CSF were detected by enzyme\u2010linked immunosorbent assay (ELISA). The confusion assessment method (CAM) was used to evaluate whether participants developed POD after surgery, and they were divided into the POD group and non\u2010POD group (NPOD). The relationship between CSF sPDGFR\u03b2, AD biomarkers, and POD was analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The level of sPDGFR\u03b2, a marker of brain pericyte injury, was significantly increased in POD patients (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05), and the difference was still statistically significant after adjusting for multiple confounders (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). CSF A\u03b242 showed a significant mediating effect between CSF sPDGFR\u03b2 level and POD (22.45%). The combination of AD biomarkers and CSF sPDGFR\u03b2 predicted POD better than that of AD biomarkers or CSF sPDGFR\u03b2 alone.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The results suggest that the increase in CSF sPDGFR\u03b2 is associated with an increased risk of POD due to the blood\u2013brain barrier (BBB) dysfunction and reduced A\u03b242 clearance. In this study, the correlation between CSF sPDGFR\u03b2 and POD was investigated for the first time, providing a new reference index for POD prediction. However, this paper did not study other relevant indicators of the BBB and lacked follow\u2010up, which could be further improved in the future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70436","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T03:07:17Z","timestamp":1746414437000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Soluble Platelet\u2010Derived Growth Factor \u03b2 Receptor Induces Postoperative Delirium by Downregulating the Clearance of \u03b2\u2010Amyloid in the Brain"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9147-3550","authenticated-orcid":false,"given":"Zongfeng","family":"Guo","sequence":"first","affiliation":[{"name":"Anesthesiology Department Hai 'an People's Hospital Affiliated to Nantong University  Hai'an 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