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This systematic literature review investigates the role of six obesity\u2010associated genes, including fat mass and obesity\u2010associated (\n                      <jats:italic>FTO<\/jats:italic>\n                      ), FAS apoptosis inhibitory molecule 2 (\n                      <jats:italic>FAIM2<\/jats:italic>\n                      ), Niemann\u2013Pick disease type C1\u2010like 1 (\n                      <jats:italic>NPC1<\/jats:italic>\n                      ), glucosamine\u20106\u2010phosphate deaminase 2 (\n                      <jats:italic>GNPDA2<\/jats:italic>\n                      ), melanocortin\u20104 receptor (\n                      <jats:italic>MC4R<\/jats:italic>\n                      ), and brain\u2010derived neurotrophic factor (\n                      <jats:italic>BDNF<\/jats:italic>\n                      ) in the context of MS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A literature search was executed using Embase, Scopus, Cochrane, Web of Science, and PubMed databases from inception to July 2024. The related keywords employed during the search process are \u201cfas apoptotic inhibitory molecule 2,\u201d \u201cNiemann\u2013Pick disease type C1,\u201d \u201cfat mass and obesity\u2010associated,\u201d \u201cmelanocortin\u20104 receptor,\u201d \u201cbrain\u2010derived neurotrophic factor,\u201d \u201cglucosamine\u20106\u2010phosphate deaminase 2,\u201d and \u201cmultiple sclerosis.\u201d<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Out of 2108 papers, 27 were entered into the present systematic literature review. The\n                      <jats:italic>FTO<\/jats:italic>\n                      gene may affect MS susceptibility through metabolic and inflammatory pathways.\n                      <jats:italic>FAIM2<\/jats:italic>\n                      and\n                      <jats:italic>NPC1<\/jats:italic>\n                      genes may contribute to MS pathogenesis, though their precise roles are still being elucidated. The\n                      <jats:italic>GNPDA2<\/jats:italic>\n                      gene may have some connections with MS but requires further clarification.\n                      <jats:italic>MC4R<\/jats:italic>\n                      has demonstrated significant neuroprotective and anti\u2010inflammatory effects, suggesting its potential impact on MS progression.\n                      <jats:italic>BDNF<\/jats:italic>\n                      plays a complex role in neuronal survival and repair and may influence the risk of MS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our findings demonstrated that obesity\u2010related genes may have a significant impact on MS risk and disease course, revealing novel insights into the genetic underpinnings of MS.<\/jats:p>\n                  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