{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T19:48:25Z","timestamp":1784836105066,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T00:00:00Z","timestamp":1746921600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Galcanezumab, approved in April 2021, is the first humanized monoclonal antibody against the calcitonin gene\u2010related peptide (CGRP) ligand to become available in Japan, but some patients with migraine are hesitant to start an anti\u2010CGRP antibody for a variety of reasons, particularly its high price. To address this, a video in Japanese called \u201cTalking Picture Book,\u201d which aims to alleviate patients\u2019 concerns about the anti\u2010CGRP antibody, was released as support material in Japan in March 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Between December 2022 and May 2023, we conducted a questionnaire survey of 34 consecutive patients who had just viewed the video in order to evaluate its effectiveness in persuading hesitant patients to start an anti\u2010CGRP antibody.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      Of these 34 patients, 79.8% gained a better understanding of migraine, 61.8% expressed a willingness to try galcanezumab, and 52.4% (11 patients) actually started the anti\u2010CGRP antibody. The number of mean monthly migraine days was significantly greater in those 11 patients than in the others. Multivariable logistic analysis of factors contributing to the decision to start anti\u2010CGRP antibody treatment revealed significant associations with monthly migraine days (odds ratio, 1.30;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01) and patients\u2019 willingness to try anti\u2010CGRP antibodies (odds ratio, 9.82;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This material was particularly useful for patients with a high number of monthly migraine days who had been hesitant to start the therapy. \u201cTalking Picture Book\u201d is a useful material that complements physicians\u2019 explanations of the therapy, and it is desirable that such video materials be adapted for use in other countries in the future.<\/jats:p>\n       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