{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:04:55Z","timestamp":1772118295978,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Schizotypy is a personality trait characterized by subclinical expression of the signs and symptoms of schizophrenia. Maladaptive schizotypy is given the clinical designation of schizotypal personality disorder. Previous studies have shown that functional disturbance of the default mode network (DMN) is associated with maladaptive schizotypy. Working memory impairment is a particularly common feature of maladaptive schizotypy and schizophrenia. As these characteristics can also be observed in the healthy population, our purpose was to identify the neural correlates of schizotypy during sustained attention tasks and working memory tasks in nonclinical subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We recruited 409 healthy individuals (251 men and 158 women; 20.7\u00a0\u00b1 1.8 [SD] years of age) and determined their schizotypy scores using the Schizotypal Personality Questionnaire. We used a typical functional MRI (fMRI) task under 0\u2010back and 2\u2010back conditions. Corrections for multiple comparisons were performed via the threshold\u2010free cluster enhancement method with a familywise error\u2010corrected threshold of\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.0167 (0.05\/3) at the whole\u2010brain level, including the cerebellum.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Suppression of deactivation of the DMN (the medial prefrontal cortex (mPFC), the posterior cingulate cortex, the inferior parietal lobule, and the middle temporal gyrus) in the working memory (2\u2010back\u00a0&gt;\u00a0rest) task and promotion of activation during the sustained attention (0\u2010back\u00a0&gt;\u00a0rest) task were associated with schizotypy scores. Among the schizotypy subscores, cognitive\u2013perceptual deficits were significantly related only to the left precuneus, the mPFC, and the superior temporal gyrus for the 2\u2010back &gt;\u00a00\u2010back contrast; to the left precuneus and the bilateral mPFC for the 2\u2010back &gt; rest contrast; and to the left superior temporal cortex and the right precuneus for the 0\u2010back &gt; rest contrast within the DMN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Disturbance of the DMN is related to the degree of schizotypy, especially to the degree of cognitive\u2012perceptual deficits, even in nonclinical subjects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70449","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T03:44:16Z","timestamp":1746589456000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Suppression of Deactivation of Working Memory and Promotion of Activation of Sustained Attention in the Default Mode Network Are Affected by Schizotypy in a Large Sample of Nonclinical Subjects"],"prefix":"10.1002","volume":"15","author":[{"given":"Seishu","family":"Nakagawa","sequence":"first","affiliation":[{"name":"Division of Psychiatry Tohoku Medical and Pharmaceutical University  Sendai Japan"},{"name":"Department of Human Brain Science, Institute of Development, Aging and Cancer Tohoku University  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hikaru","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer Tohoku University  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Taki","sequence":"additional","affiliation":[{"name":"Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer Tohoku University  Sendai Japan"},{"name":"Division of Medical Neuroimage Analysis, Department of Community Medical Supports, Tohoku Medical Megabank Organization Tohoku University  Sendai Japan"},{"name":"Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer Tohoku University  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoichi","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Extended Intelligence for Medicine, The Ishii\u2010Ishibashi Laboratory Keio University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Sakaki","sequence":"additional","affiliation":[{"name":"Department of Advanced Brain Science, Institute of Development, Aging and Cancer Tohoku University  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelssy Hitomi dos Santos","family":"Kawata","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Graduate School of Interdisciplinary Information Studies The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Nozawa","sequence":"additional","affiliation":[{"name":"Faculty of Engineering University of Toyama  Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Yokota","sequence":"additional","affiliation":[{"name":"Faculty of Arts and Science Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Araki","sequence":"additional","affiliation":[{"name":"ADVANTAGE Risk Management Co., Ltd.  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Nouchi","sequence":"additional","affiliation":[{"name":"Creative Interdisciplinary Research Division, Frontier Research Institute for Interdisciplinary Science (FRIS) Tohoku University  Sendai Japan"},{"name":"Smart Aging International Research Center, Institute of Development, Aging and Cancer Tohoku University  Sendai Japan"},{"name":"Human and Social Response Research Division, International Research Institute of Disaster Science Tohoku University  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuta","family":"Kawashima","sequence":"additional","affiliation":[{"name":"Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer Tohoku University  Sendai Japan"},{"name":"Department of Advanced Brain Science, Institute of Development, Aging and Cancer Tohoku University  Sendai Japan"},{"name":"Smart Aging International Research Center, Institute of Development, Aging and Cancer Tohoku University  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573405617666210114142206"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888\u2010018\u20101908\u20103"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbu191"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-813201-2.00005-3"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.12.2209"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2013.08.016"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3758\/s13423\u2010021\u201002052\u20102"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbu190"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.5.781"},{"key":"e_1_2_10_11_1","volume-title":"StatPearls","author":"Francois Z.","year":"2024"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2006.06.017"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00239"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13514"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264\u2010016\u20100090\u20101"},{"key":"e_1_2_10_16_1","first-page":"29","article-title":"Development of a Japanese Version of the Schizotypal Personality Questionnaire and Factor Structure of Schizotypy","volume":"36","author":"Iijima Y.","year":"2010","journal-title":"Koudouryouhoukenkyu"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.10.010"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2007.04.006"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058130"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1162\/089892903321593117"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.116791"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.30773\/pi.2020.0438"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.01.004"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.1058"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2007.07.023"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.018"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/17.4.555"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/20.1.191"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1006\/cogp.1999.0735"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.21500\/20112084.5292"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/texcom\/tgac035"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.4329\/wjr.v6.i6.261"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.04.020"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/13546805.2017.1299702"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.03.061"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpsm.2020.08.001"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.11.052"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr371"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.01.053"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1037\/bul0000260"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2013.09.013"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25618"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010clinpsy\u2010032511\u2010143049"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0809141106"},{"key":"e_1_2_10_45_1","first-page":"115","volume-title":"The Wiley Encyclopedia of Personality and Individual Differences","author":"Wong K. K.\u2010Y.","year":"2020"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40473-018-0144-y"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682\u2010019\u201000071\u20101"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2010.08.027"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.70449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:34:13Z","timestamp":1748306053000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.70449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/brb3.70449"],"URL":"https:\/\/doi.org\/10.1002\/brb3.70449","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.70449\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70449\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70449\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70449\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70449\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70449\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70449\/v3\/response1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2023-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70449"}}