{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T10:19:10Z","timestamp":1778494750511,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To analysis the basic characteristics, comorbidities and prognosis of elderly patients with Late\u2010Onset Epilepsy (LOE) in the Eastern Region of Hefei, Anhui.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This study finally selected 304 participants who were enrolled at the Second People's Hospital of Hefei between January 2018 and December 2023. The analysis included baseline characteristics, etiology, seizure types, findings from electroencephalography (EEG) and cranial magnetic resonance imaging, comorbidities, anti\u2010seizure medication (ASM) regimens, and follow\u2010up of seizure control outcomes within one year. Continuous variables were presented as mean \u00b1 standard deviation (SD) or median (IQR) based on normality. Categorical variables were compared using the chi\u2010square test with Bonferroni correction for multiple comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>According to our study, ischemic cerebral infarction (41.12%) was the main factor for LOE in elderly patients among structural factors. Focal seizure (92.76%) was the main seizure type. The most common comorbidity was ischemic cerebral infarction (88.16%), followed by cerebral hemorrhage (22.37%). During the one year follow\u2010up, the overall effectiveness of seizure control was 73.03%, and 49.34% patients were seizure\u2010free. The one\u2010year treatment efficacy of patients with comorbid psychiatric disorders, cognitive impairment or dementia were significantly lower than that of patients without these comorbidities. In terms of medications, sodium valproate accounted for the most at 86.84%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Structural factors are the main etiology for LOE in elderly patients, with ischemic cerebral infarction accounting for the highest proportion. Focal seizure was the main seizure type. Patients with comorbid psychiatric disorders, cognitive impairment or dementia may have poor one\u2010year treatment efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70452","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T02:38:55Z","timestamp":1745289535000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Features and Prognostic Analysis of Elderly Patients With Late\u2010Onset Epilepsy"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5445-3736","authenticated-orcid":false,"given":"Jie","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Neurology Hefei Hospital Affiliated to Anhui Medical University (The Second People's Hospital of Hefei) Hefei Anhui China"},{"name":"Department of Neurology The Fifth Clinical Medical College of Anhui Medical University Hefei Anhui 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