{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:04:55Z","timestamp":1772118295909,"version":"3.50.1"},"reference-count":71,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["2022R1A4A1018869"],"award-info":[{"award-number":["2022R1A4A1018869"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS\u20102025\u201000515755"],"award-info":[{"award-number":["RS\u20102025\u201000515755"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Visuospatial impairment is one of the most frequent cognitive deficits in patients with Parkinson's disease (PD). It remains unknown whether the vestibulo\u2010ocular reflex (VOR) function affects visuospatial perception and memory in patients with PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To delineate the relationship between VOR and visuospatial function in patients with PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We prospectively evaluated video head\u2010impulse tests in 151 patients with PD (mean age  standard deviation, 68  9 years; 77 male). All patients conducted the Rey Complex Figure test (RCFT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      RCFT\u2010copying and RCFT\u2010delayed recall were impaired in 11 (11\/151, 7%) and 15 (15\/151, 10%) patients, respectively. The VOR gain was normal in 55 patients with PD (55\/151, 36%). However, 69 patients overestimated VOR gain for at least one canal, and 34 patients showed a decreased gain for at least one canal (seven patients showed an overestimated gain for some canals and decreased gain for other canals). Multivariable logistic regression analysis showed that abnormal RCFT\u2010copying was negatively associated with the VOR gain for the horizontal canal (odds ratio [OR]: 0.001, 95% confidence interval [CI]: 0.001\u20130.08,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.007). In contrast, abnormal RCFT\u2010delayed recall was negatively associated with Mini\u2010Mental State Examination scores (0.70, 0.52\u20130.93,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.013), positively with age (1.11, 1.00\u20131.22,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.041), male sex (12.82, 1.17\u2013142.86,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.036), years of schooling (1.41, 1.09\u20131.82,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.009), but not with the VOR gain for any canal.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The VOR function may be associated with deficits in visuospatial perception and learning in patients with PD. This implicates the development of more targeted therapeutic interventions and offers insights into the broader implications of PD on sensory\u2010motor integration and cognitive function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70453","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T01:10:03Z","timestamp":1743729003000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Vestibulo\u2010Ocular Reflex is Associated With Visuospatial Dysfunction in Patients With Parkinson's Disease"],"prefix":"10.1002","volume":"15","author":[{"given":"Yukang","family":"Kim","sequence":"first","affiliation":[{"name":"Neurotology and Neuro\u2010ophthalmology Laboratory Korea University Medical Center  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonghoon","family":"Woo","sequence":"additional","affiliation":[{"name":"Neurotology and 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