{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:55:48Z","timestamp":1790880948602,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Observational studies have associated obstructive sleep apnea (OSA) with a higher risk of various cancers; however, causal relationships have not yet been definitively established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our study evaluated the causal impact of OSA on the risk of developing 22 different types of cancer using univariable and multivariable Mendelian randomization (MR). OSA\u2010associated genetic instruments were obtained from the FinnGen study, which incorporates 38,998 OSA individuals and 336,659 non\u2010OSA individuals from European descent. Summary\u2010level data for 22 site\u2010specific cancers were estimated from large genetic consortia and UK Biobank. We used inverse\u2010variance weighting (IVW) as the primary analysis, along with several sensitivity analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Univariable MR analyses indicated a causal relationship of genetic susceptibility to OSA on an increased risk of Barrett's esophagus (BE) and esophageal cancer (odds ratio [OR] = 1.32, 95% confidence interval [CI] = 1.07\u22121.62, <jats:italic>p<\/jats:italic> = 0.01), endometrial cancer (OR = 1.36, 95% CI = 1.16\u22121.60, <jats:italic>p<\/jats:italic> = 2.26E\u201004), and its endometrioid subtype (OR = 1.28, 95% CI = 1.04\u22121.59, <jats:italic>p<\/jats:italic> = 0.02). Multivariable MR, accounting for possible confounders like drinking and smoking, confirmed the causal relationships of OSA on BE and esophageal cancer, and endometrial cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study provided evidence regarding causal associations of OSA with higher risk of BE and esophageal cancer, and endometrial cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.70462","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T08:29:08Z","timestamp":1746433748000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Causal Associations of Obstructive Sleep Apnea With Cancer Risk: A Mendelian Randomization Study"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0148-8891","authenticated-orcid":false,"given":"Xiaoyu","family":"He","sequence":"first","affiliation":[{"name":"Department of Hematology The Second Affiliated Hospital of Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Ye","sequence":"additional","affiliation":[{"name":"People's Hospital of Zhenhai  Ningbo Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiqian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenjiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Affiliated Hospital of Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2006.06.037"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00185110"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201310-1830OC"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2016.tb00709.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv080"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21965"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21758"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwu283"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-017-0276-5"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1408"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000028930"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/28867"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11132051"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.022560"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2019.02.016"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2022.04.015"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202108-960OC"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2020.106455"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-55551-7"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3030"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.17219"},{"issue":"8","key":"e_1_2_9_23_1","first-page":"1311","article-title":"Obstructive Sleep Apnea Is a Common Disorder in the Population\u2014A Review on the Epidemiology of Sleep Apnea","volume":"7","author":"Franklin K. 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