{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:03:00Z","timestamp":1772118180856,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81300981"],"award-info":[{"award-number":["81300981"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671120"],"award-info":[{"award-number":["81671120"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171431"],"award-info":[{"award-number":["82171431"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20377"],"award-info":[{"award-number":["U22A20377"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2022JJ30979"],"award-info":[{"award-number":["2022JJ30979"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA0805202"],"award-info":[{"award-number":["2021YFA0805202"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neuroimaging has been increasingly used to assess brain structural alterations in patients with amyotrophic lateral sclerosis (ALS). We aimed to investigate alterations in brain sub\u2010cortical structures and to identify potential neuroimaging biomarkers for disease progression for patients with ALS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 61 patients with ALS were prospectively enrolled and were divided into three subgroups according to disease progression, i.e., fast, intermediate, and slow progression. Sixty\u2010one matched healthy controls (HCs) were also recruited. All participants acquired a brain structural magnetic resonance imaging scan for subcortical volumetric and shape analyses. Neuropsychological testing and functional assessment were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with fast progression showed significant shape alterations in basal ganglia and brainstem as compared to the HCs group. In ALS patients with fast progression, shape contractions with atrophic changes were noted in bilateral nucleus accumbens, left caudate, left thalamus, and brainstem; while shape expansion with hypertrophy was noted in the left caudate, left thalamus, and left pallidum (all\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). There were significant positive correlations of the shape changes of the left thalamus with the Amyotrophic Lateral Sclerosis Functional Rating Scale\u2010Revised (ALS\u2010FRS\u2010R) total and limb scores and with disease duration (all\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). There were positive correlations of left pallidum with anxiety or with disease duration, and of left nucleus accumbens with ALS\u2010FRS\u2010R total or bulbar score, and of brainstem with mini\u2010mental state examination score (all\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Extensive shape alterations of subcortical nuclei were noted in patients with fast progression of ALS, implicating subcortical shape being a potential neuroimaging biomarker for ALS progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70495","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T04:26:33Z","timestamp":1747628793000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Shape Alterations of Subcortical Nuclei Correlate With Amyotrophic Lateral Sclerosis Progression"],"prefix":"10.1002","volume":"15","author":[{"given":"Yanchun","family":"Yuan","sequence":"first","affiliation":[{"name":"Xiangya Hospital Central South University, Jiangxi (National Regional Center for Neurological Diseases) Nanchang Jiangxi P. R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Radiology Xiangya Hospital, Central South University Changsha Hunan P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Xiangya Hospital, Central South University Changsha Hunan P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Hu","sequence":"additional","affiliation":[{"name":"Xiangya Hospital Central South University, Jiangxi (National Regional Center for Neurological Diseases) Nanchang Jiangxi P. R. China."},{"name":"Jiangxi Provincial People's Hospital, Clinical College of Nanchang Medical College First Affiliated Hospital of Nanchang Medical College Nanchang Jiangxi P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianqian","family":"Zhao","sequence":"additional","affiliation":[{"name":"Xiangya Hospital Central South University, Jiangxi (National Regional Center for Neurological Diseases) Nanchang Jiangxi P. R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cailin","family":"He","sequence":"additional","affiliation":[{"name":"Xiangya Hospital Central South University, Jiangxi (National Regional Center for Neurological Diseases) Nanchang Jiangxi P. R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linxin","family":"Tang","sequence":"additional","affiliation":[{"name":"Xiangya Hospital Central South University, Jiangxi (National Regional Center for Neurological Diseases) Nanchang Jiangxi P. R. 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