{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:08:41Z","timestamp":1782475721453,"version":"3.54.5"},"reference-count":73,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["N2620\u2010R"],"award-info":[{"award-number":["N2620\u2010R"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Stroke disrupts functional brain connectivity, yet how this relates to lower limb motor and sensory abilities is not well understood. Greater knowledge of movement\u2010related brain connectivity can aide in the development of better interventions for recovery after stroke. Our objective was to evaluate the relationship between lower limb performance and resting\u2010state functional connectivity (rsFC) of large\u2010scale brain networks for individuals with chronic motor deficits (&gt; 6 months) after stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Resting\u2010state functional magnetic resonance imaging and lower limb clinical measures were collected for 37 individuals. Regions of interest (ROI)\u2010to\u2010ROI connectivity analysis was conducted for cortical sensorimotor network (SMN) (cortical SMN), SMN with both cortical and subcortical ROIs (SMN), and default mode network (DMN). Relationship of ROI\u2013ROI connectivity and clinical measures or lesion load was assessed using general linear models. Graph theory metrics (global efficiency, clustering coefficient, and betweenness centrality) were related to clinical measures using elastic nets analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Greater connectivity between several SMN and DMN ROI pairs was associated with better gait speed, Timed\u2010Up\u2010and\u2010Go score, and monofilament perception. The majority of ROI pairs showing statistically significant relationship with clinical measures were interhemispheric, non\u2010homologous, and cortical\u2010to\u2010subcortical. Elastic net analysis for graph theory metrics revealed complexity and multi\u2010directionality of the relationship of the individual ROIs to clinical outcomes and lesion load. There were unique sets of ROIs associated with each clinical measure for different graph metrics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>rsFC between specific ROIs within SMN and DMN are related to lower limb performance. Non\u2010homologous interhemispheric ROI\u2010to\u2010ROI connectivity was featured in the analysis. Graph theory analysis demonstrates the complex role that an individual ROI has in relation to sensorimotor function of lower extremity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Clinicialtrials.gov registration number NCT03666533<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70519","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:34:04Z","timestamp":1748306044000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Resting\u2010State Functional Connectivity of Sensorimotor and Default Mode Networks and Lower Limb Performance in Chronic Stroke: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7262-458X","authenticated-orcid":false,"given":"Svetlana","family":"Pundik","sequence":"first","affiliation":[{"name":"Department of Veterans Affairs Northeast Ohio Healthcare System (VANEOHS)  Cleveland Ohio USA"},{"name":"School of Medicine Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret M.","family":"Skelly","sequence":"additional","affiliation":[{"name":"Department of Veterans Affairs Northeast Ohio Healthcare System (VANEOHS)  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica P.","family":"McCabe","sequence":"additional","affiliation":[{"name":"Department of Veterans Affairs Northeast Ohio Healthcare System (VANEOHS)  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahlam I.","family":"Salameh","sequence":"additional","affiliation":[{"name":"Department of Veterans Affairs Northeast Ohio Healthcare System (VANEOHS)  Cleveland Ohio USA"},{"name":"School of Medicine Case Western Reserve University  Cleveland Ohio USA"},{"name":"Department of Biomedical Engineering Case Western Reserve University  Cleveland Ohio USA"},{"name":"Division of Preclinical Sciences Kent State University College of Podiatric Medicine  Independence Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trenley","family":"Anderson","sequence":"additional","affiliation":[{"name":"School of Medicine Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey Rose","family":"Duncan","sequence":"additional","affiliation":[{"name":"Department of Veterans Affairs Northeast Ohio Healthcare System (VANEOHS)  Cleveland Ohio USA"},{"name":"University Hospitals of Cleveland Case Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terri","family":"Hisel","sequence":"additional","affiliation":[{"name":"Department of Veterans Affairs Northeast Ohio Healthcare System (VANEOHS)  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6641-4415","authenticated-orcid":false,"given":"Sarah J. 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