{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T18:01:18Z","timestamp":1779386478626,"version":"3.53.1"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Lonicerin (LON) has been identified to have different biological properties, such as anticancer, anti\u2010inflammatory, immunomodulatory, antibacterial, antimicrobial, and neuroprotective. This study aims to assess the sedative effect of LON in Swiss albino mice, which is yet to be discovered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Mice were treated with two different doses of LON (5 and 10\u00a0mg\/kg) and 2\u00a0mg\/kg of diazepam (DZP), which is the referral GABAergic medication, and the latency time and sleeping duration of animals were observed. A computational study was also conducted to evaluate the docking scores and display the binding sites of LON and receptor (GABA\n                      <jats:sub>A<\/jats:sub>\n                      \u03b11 and \u03b22 subunits). The study also investigated the pharmacokinetics and drug\u2010likeness properties of LON along with toxicological analysis by using SwissADME and Protox\u20103 software, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Findings revealed that the higher concentration of LON reduced the latency (9.86\u00a0\u00b1\u00a01.44\u00a0min) and increased the sleep duration (191.29\u00a0\u00b1\u00a07.43\u00a0min) compared to the lower concentration. Besides, the combination group of LON and DZP showed the lowest latency (6.17\u00a0\u00b1\u00a00.82\u00a0min) and highest sleeping time (219.00\u00a0\u00b1\u00a06.39\u00a0min). In the in silico study, LON exhibited a strong docking score (\u22128.1\u00a0kcal\/mol) with the macromolecules, which is closer to the binding affinity of DZP (\u20138.3\u00a0kcal\/mol), indicating that LON could show strong sedative activity by binding with the GABA\n                      <jats:sub>A<\/jats:sub>\n                      receptor. Computational toxicity analysis revealed that LON is non\u2010hepatotoxic, non\u2010neurotoxic, noncarcinogenic, noncytotoxic, non\u2010ecotoxic, and non\u2010mutagenic.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Therefore, LON may be effective for the treatment of insomnia in the near future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70524","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T03:45:46Z","timestamp":1746416746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of Sedative Activity of Lonicerin: In Vivo Approach With Pharmacokinetics and Molecular Docking"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0282-1818","authenticated-orcid":false,"given":"Tanzila Akter","family":"Eity","sequence":"first","affiliation":[{"name":"Department of Biotechnology and Genetic Engineering Gopalganj Science and Technology University  Gopalganj Bangladesh"},{"name":"Bioinformatics and Drug Innovation Laboratory BioLuster Research Center Ltd.  Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6179-9720","authenticated-orcid":false,"given":"Md. Shimul","family":"Bhuia","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Gopalganj Science and Technology University  Gopalganj Bangladesh"},{"name":"Bioinformatics and Drug Innovation Laboratory BioLuster Research Center Ltd.  Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0672-6581","authenticated-orcid":false,"given":"Raihan","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Gopalganj Science and Technology University  Gopalganj Bangladesh"},{"name":"Bioinformatics and Drug Innovation Laboratory BioLuster Research Center Ltd.  Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3705-6967","authenticated-orcid":false,"given":"Salehin","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Gopalganj Science and Technology University  Gopalganj Bangladesh"},{"name":"Bioinformatics and Drug Innovation Laboratory BioLuster Research Center Ltd.  Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddique Akber","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry College of Pharmacy King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nowreen Tabassum","family":"Ahammed","sequence":"additional","affiliation":[{"name":"Department of Biology Touro University  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossam","family":"Kamli","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Sciences King Khalid University  Abha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6392-3820","authenticated-orcid":false,"given":"Muhammad Torequl","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Gopalganj Science and Technology University  Gopalganj Bangladesh"},{"name":"Bioinformatics and Drug Innovation Laboratory BioLuster Research Center Ltd.  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