{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:49:12Z","timestamp":1780494552419,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Asthma is a common chronic respiratory disease, and its potential association with the central nervous system has garnered increasing attention in recent years. While observational studies suggest that asthma may affect hippocampal structure and function through mechanisms such as chronic inflammation and hypoxia, its causal relationship remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we employed a two\u2010sample Mendelian randomization (MR) analysis, utilizing large\u2010scale genome\u2010wide association study (GWAS) data to systematically investigate the potential causal relationship between asthma and hippocampal volume. Data from a GWAS of asthma involving 155,386 individuals of European ancestry and GWAS imaging\u2010derived phenotypes (IDPs) of hippocampal volume from 33,219 European individuals were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results revealed a significant negative correlation between asthma and multiple hippocampal IDPs (<jats:italic>P<\/jats:italic><jats:sub>FDR<\/jats:sub> &lt; 0.05), indicating that asthma may contribute to reduced hippocampal volume. We identified 19 independent SNPs significantly associated with asthma (<jats:italic>P<\/jats:italic> &lt; 5\u00d710\u207b\u2078), of which 16 SNPs were retained after clumping (r<jats:sup>2<\/jats:sup> &lt; 0.001) and harmonization. Sensitivity analyses revealed no heterogeneity or horizontal pleiotropy, and reverse MR analysis did not support a causal effect of hippocampal volume on asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study provides genetic evidence for a causal relationship between asthma and changes in hippocampal volume, highlighting the need for closer monitoring and intervention in the neurocognitive health of asthma patients in clinical practice. Future studies should explore the causal relationship between asthma and brain structural changes across different racial groups and asthma subtypes, as well as the underlying biological mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.70560","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T13:30:14Z","timestamp":1748266214000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Causal Relationship Between Asthma and Hippocampal Volume: A Study Based on Bidirectional Mendelian Randomization Analysis"],"prefix":"10.1002","volume":"15","author":[{"given":"Dandan","family":"Han","sequence":"first","affiliation":[{"name":"Medical Imaging Center Xuchang Central Hospital Affiliated to Henan University of Science and Technology  Xuchang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4448-244X","authenticated-orcid":false,"given":"Shaohua","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Xuchang Central Hospital Affiliated to Henan University of Science and Technology  Xuchang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2389\u201021.2022"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011\u2010022\u201000907\u20108"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.027544"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2021.01.019"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.09.029"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000528626"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv080"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21965"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.09.014"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000559"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280215597579"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyr036"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2016.1186174"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2021.100360"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crimmu.2021.11.001"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23148002"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079\u20106123(10)82002\u20103"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.17219"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010023\u201003863\u20101"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6522"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.03160\u20102021"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyx102"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.4149\/gpb_2023001"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI124609"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.25322"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2023.105063"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.04.012"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13501"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.251"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01660"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072\u2010021\u201005810\u20101"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/diseases12120300"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/02698811231190859"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.663535"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2020.08.022"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682\u2010019\u201000188\u20103"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01018.2018"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01397\u20102023"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242216042"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2021.105535"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/pch\/17.5.e34"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010021\u201000826\u20104"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000699"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abl5163"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2020.113527"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2022.2119865"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2018.09.006"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.70560","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T04:34:26Z","timestamp":1748320466000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.70560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/brb3.70560"],"URL":"https:\/\/doi.org\/10.1002\/brb3.70560","archive":["Portico"],"relation":{},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2024-10-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70560"}}