{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:28:28Z","timestamp":1792272508134,"version":"4.4.0"},"reference-count":54,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Alzheimer's disease (AD) is a neurodegenerative disease primarily manifesting with cognitive decline. This study aimed to investigate the alterations in microRNAs in patients across AD continuum as potential biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      Data were extracted from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database, including microRNA levels in the serum and cerebrospinal fluid (CSF) of patients across AD continuum. We analyzed the associations between microRNA levels and previously known AD biomarkers, such as amyloid beta (A\u03b2) accumulations in the brain and glucose reuptake values using positron emission tomography ([\n                      <jats:sup>18<\/jats:sup>\n                      F]AV45 and FDG PET, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>The study found a significant positive correlation between CSF levels of miR\u2010210\u20103p and A\u03b2 accumulations in the brain (B = 4.69). Conversely, miR\u2010223\u20103p levels were significantly lower in APOE\u2010\u03b54 carriers. Significant negative correlations were also observed between glucose reuptake and several miRNAs in the AD group. Specifically, plasma levels of let\u20107g\u20105p, mir\u2010423\u20105p, and mir\u2010660\u20105p were negatively associated with glucose reuptake in the brain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevated levels of miR\u2010210\u20103p correlate with A\u03b2 accumulation, supporting previous findings of increased levels of certain\u00a0microRNAs\u00a0in patients with MCI and AD. Our findings highlight the potential of microRNAs as biomarkers of AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70572","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T13:24:27Z","timestamp":1748265867000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["MicroRNA Signatures Predict Brain Amyloidosis and Neurodegeneration in Alzheimer\u2019s Disease: Insights from [\n                    <sup>18<\/sup>\n                    F] AV45 and FDG PET Imaging"],"prefix":"10.1002","volume":"15","author":[{"given":"Parsa","family":"saberian","sequence":"first","affiliation":[{"name":"Student Research Committee, Faculty of Medicine Hormozgan University of Medical Sciences  Bandar Abbas Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0584-8750","authenticated-orcid":false,"given":"Afra","family":"Darvishi","sequence":"additional","affiliation":[{"name":"Student Research Committee Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delnia","family":"khezragha","sequence":"additional","affiliation":[{"name":"Faculty of Science University of Tabriz  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moojan","family":"Forouzandegan","sequence":"additional","affiliation":[{"name":"Students' Scientific Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad\u2010Erfan","family":"Farhadieh","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Sciences and Technology University of Isfahan  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaghayegh","family":"Taghizadeh Khorshidi","sequence":"additional","affiliation":[{"name":"Institute for Cognitive Science Studies  Pardis Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9655-0434","authenticated-orcid":false,"given":"Mohamad","family":"Hatami Nejad","sequence":"additional","affiliation":[{"name":"Department of Psychology, Faculty of Psychology and Educational Sciences University of Tehran  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Sedighi","sequence":"additional","affiliation":[{"name":"Department of Psychology, Faculty of Psychology and Educational Sciences University of Tehran  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Barati","sequence":"additional","affiliation":[{"name":"School of Medicine Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Ahmad Reza","family":"Safavi","sequence":"additional","affiliation":[{"name":"Poursina Clinical Research Development Unit Guilan University of Medical Sciences  Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"School of Medicine Tehran University of Medical Sciences  Tehran Iran"},{"name":"School of Rehabilitation Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gulisashvili","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology &amp; 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