{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T14:59:59Z","timestamp":1772117999919,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Human Herpesvirus 6 (HHV\u20106) infections are primarily observed in immunocompromised individuals, such as those with acquired immunodeficiency syndrome or organ transplant recipients. However, its role as a pathogen in immunocompetent adults remains debated. We aimed to explore the clinical significance of HHV\u20106 in immunocompetent individuals by presenting a case of HHV\u20106\u2010associated meningitis with concurrent lymphadenitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We describe a case of an immunocompetent adult presenting with recurrent fever and headaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Finding<\/jats:title>\n                    <jats:p>Diagnostic evaluations included next\u2010generation sequencing analysis identified HHV\u20106 in both cerebrospinal fluid specimens and lymphoid tissue samples. The patient demonstrated complete clinical resolution following a 14\u2010day course of ganciclovir therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case underscores the need to consider HHV\u20106 infection in immunocompetent adults presenting with meningitis of unknown etiology. Early detection and targeted antiviral therapy may lead to favorable clinical outcomes<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70590","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T06:10:53Z","timestamp":1748585453000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Human Herpesvirus\u20106 Infectious Meningitis With Lymphadenitis in an Immunocompetent Adult"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2795-195X","authenticated-orcid":false,"given":"Yu","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Neurology Zhongnan Hospital of Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenrui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhongnan Hospital of Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingchi","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhongnan Hospital of Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziqian","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhongnan Hospital of Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhongnan Hospital of Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yimiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhongnan Hospital of Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhongnan Hospital of Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanteng","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhongnan Hospital of Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhongnan Hospital of Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhongnan Hospital of Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-013-1902-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00122-14"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2016.09.004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2020-239220"},{"issue":"6","key":"e_1_2_9_6_1","first-page":"3413","article-title":"HHV\u20106\u2010Associated Acute Lymphadenitis in Immunocompetent Patients: A Case Report and Review of Literature","volume":"7","author":"Bai Y.","year":"2014","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001121"},{"issue":"11","key":"e_1_2_9_8_1","article-title":"Human Herpesvirus 6 (HHV\u20106) Encephalitis in a Non\u2010Transplant Patient With Polymyositis","volume":"13","author":"Baleguli V.","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2008.08.017"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-024-04387-5"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2013.06.015"},{"issue":"6","key":"e_1_2_9_12_1","article-title":"Incidental Detection of Human Herpesvirus\u20106 in Cerebrospinal Fluid Analysis: To Treat or Not to Treat?","volume":"14","author":"Kharbat A. F.","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1179547620912952"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/08998280.2020.1719784"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.27.4.651-653.1989"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00313-20"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/v9070194"},{"issue":"5","key":"e_1_2_9_18_1","article-title":"A Rare Case of Human Herpesvirus 6 Meningitis in an Immunocompetent Asian Male Presented With a Severe Intractable Headache","volume":"13","author":"Patel R.","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/589747"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.70590","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T07:44:00Z","timestamp":1755071040000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.70590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,30]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/brb3.70590"],"URL":"https:\/\/doi.org\/10.1002\/brb3.70590","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.70590\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70590\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70590\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70590\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70590\/v1\/review2","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,30]]},"assertion":[{"value":"2025-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70590"}}