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According to previous reports, <jats:italic>Coriolus versicolor<\/jats:italic> (CV) has a protective effect on the brain. The goal of the current investigation was to assess how CV affected the neurobehavioral and metabolic changes caused by VPA in mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Mice pups were injected with VPA at 14\u00a0days of age and orally administered CV at a dose of 200\u00a0mg\/kg daily from 14 to 40\u00a0days of age. Mice pups were placed through behavioral tests during the trial to evaluate motor skill growth, nociceptive response, locomotion, anxiety, and cognition. Following behavioral testing, mice were killed, and the brain was removed and subjected to biochemical analyses (glutathione, malondialdehyde, and nitric oxide) and histopathological analysis. Additionally, to further investigate the role of the TLR\u20104\/Myd88\/NF\u2010\u03baB signaling pathway, we examined the modulation of this pathway and the alteration in gamma\u2010amino butyric acid (GABA) production using Western blot analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>According to our research, CV daily administration greatly reduced behavioral alteration, reversed the disorganization of the cerebellum and hippocampus, and significantly improved the VPA\u2010induced neuroinflammation via the TLR\u20104\/Myd88\/NF\u2010\u03baB signaling cascade.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.70591","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T03:44:53Z","timestamp":1749008693000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["\u2060\u2060Functional Foods Alleviate Behavioral Alterations and Improve GABAergic System 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