{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:15:30Z","timestamp":1784762130307,"version":"3.55.0"},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study investigates whether anodal high\u2010definition transcranial direct current stimulation (HD\u2010tDCS) enhances exercise\u2010induced hypoalgesia (EIH) and explores brain plasticity changes using functional near\u2010infrared spectroscopy (fNIRS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010nine participants were randomly assigned to either the active (\n                      <jats:italic>n<\/jats:italic>\n                      = 19) or sham HD\u2010tDCS (\n                      <jats:italic>n<\/jats:italic>\n                      = 20) group. Both groups performed 25 min of moderate\u2010intensity aerobic exercise followed by 20 min of either active or sham HD\u2010tDCS applied to the left primary motor cortex (M1). Primary outcome: pressure pain threshold (PPT) at a local site. Secondary outcomes: PPT at a remote site, cold pain threshold (CPT), and brain activation changes via fNIRS during the cold pressor test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both groups showed significant increases in PPT\n                      <jats:sub>leg<\/jats:sub>\n                      (active: from 42.21 \u00b1 11.77 N to 51.29 \u00b1 12.75 N; sham: from 41.41 \u00b1 9.73 N to 45.29 \u00b1 12.05 N,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) and PPT\n                      <jats:sub>forearm<\/jats:sub>\n                      (active: from 31.69 \u00b1 6.06 N to 36.99 \u00b1 6.35 N; sham: from 32.66 \u00b1 7.34 N to 37.08 \u00b1 10.56 N,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). The active group showed a significantly greater increase in PPT\n                      <jats:sub>leg<\/jats:sub>\n                      compared to the sham group (9.08 \u00b1 8.01 N vs. 3.69 \u00b1 4.36 N,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.012). fNIRS analysis revealed significant changes in specific cortical channels in the active group (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05), with a negative correlation between cortical activation in CH16 and PPTleg (\n                      <jats:italic>r<\/jats:italic>\n                      = \u22120.405,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.011).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HD\u2010tDCS over M1 enhances EIH and is associated with increased brain activation in sensory\u2010motor processing areas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Clinical trial registration: ChiCTR2100048146<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70595","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T02:19:31Z","timestamp":1749608371000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["High\u2010Definition Transcranial Direct Current Stimulation Enhances Exercise\u2010Induced Hypoalgesia in Healthy Individuals: An fNIRS Study"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8249-8126","authenticated-orcid":false,"given":"Ruihan","family":"Wan","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine The Sixth Affiliated Hospital of Sun Yat\u2010Sen 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