{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:31:47Z","timestamp":1786977107819,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study explores the diagnostic, treatment, and follow\u2010up approaches of neurologists, psychiatrists, and family physicians in managing late\u2010onset bipolar disorder (BD) in elderly patients, emphasizing the role of interdisciplinary collaboration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cross\u2010sectional survey involved 300 specialists (100 from each discipline). The survey assessed diagnostic accuracy, treatment preferences, follow\u2010up adherence, and barriers to interdisciplinary collaboration. A pairwise\n                      <jats:italic>z<\/jats:italic>\n                      \u2010test with Bonferroni correction was applied for comparative analysis across specialties to evaluate differences in response proportions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Neurologists demonstrated high proficiency in imaging and treatment initiation (91% correct imaging responses) but faced challenges in holistic management and follow\u2010up adherence (2%). Psychiatrists excelled in diagnosing organic causes of mood disorders (92%) and therapeutic decisions but struggled with non\u2010priority diagnostic tests (44%) and long\u2010term follow\u2010up strategies (14%). Family physicians showed strong skills in pharmacological management (96%) and follow\u2010up adherence (89%) but encountered barriers like stigma and referral timing for high\u2010risk cases. Common interdisciplinary challenges included diagnostic communication, treatment coordination, and follow\u2010up collaboration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Late\u2010onset BD management requires a multidisciplinary approach to address specialty\u2010specific gaps and foster effective interdisciplinary collaboration. Enhanced training, integrated care models, and shared guidelines are recommended to optimize outcomes for elderly patients with mood disorders. Future research should focus on developing standardized protocols and evaluating the long\u2010term impact of interdisciplinary interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70611","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T02:23:28Z","timestamp":1749608608000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Revisiting Late\u2010Onset Bipolar Disorder Associated With Pituitary Adenoma: A Cross\u2010Sectional, Multidisciplinary, Case\u2010Based Analysis"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7507-2290","authenticated-orcid":false,"given":"Yagmur Sever","family":"Fidan","sequence":"first","affiliation":[{"name":"Erenkoy Mental and Nervous Diseases Training and Research Hospital Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1492-6763","authenticated-orcid":false,"given":"Ikbal Humay","family":"Arman","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Family Medicine Istanbul Medipol University Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumeyye Yasemin","family":"Calli","sequence":"additional","affiliation":[{"name":"Erenkoy Mental and Nervous Diseases Training and Research Hospital Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3576-0344","authenticated-orcid":false,"given":"Fusun Mayda","family":"Domac","sequence":"additional","affiliation":[{"name":"Erenkoy Mental and Nervous Diseases Training and Research Hospital Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine Nese","family":"Yeniceri","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Family Medicine Mugla Sitki Kocman University Mugla Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahar","family":"Tasdelen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Biostatistics and Medical Informatics Mersin University Mersin Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aynur","family":"Ozge","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Biostatistics and Medical Informatics Mersin University Mersin Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4957"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57060587"},{"issue":"3","key":"e_1_2_11_4_1","first-page":"27","article-title":"Roles of Primary Care Physicians in Managing Bipolar Disorders in Adults","volume":"10","author":"Awaluddin A.","year":"2015","journal-title":"Malaysian Family Physician"},{"issue":"4","key":"e_1_2_11_5_1","first-page":"1254","article-title":"Transdisciplinary Approach in Type I Neurofibromatosis\u2014Review of Psychiatric Disorders","volume":"33","author":"Bogadi M.","year":"2021","journal-title":"Psychiatria Danubina"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920\u2010024\u201001483\u20107"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010020\u20100796\u20108"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.1046471"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/581976"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/2194\u20107511\u20101\u201015"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v69n0415"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/14782715231197577"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.09.019"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.39278"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12175754"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2008.06.006"},{"issue":"3","key":"e_1_2_11_17_1","first-page":"161","article-title":"Structural Brain Abnormalities and Mental Disorders: A Neuroimaging Perspective","volume":"8","author":"Roca M.","year":"2015","journal-title":"Revista De Psiquiatr\u00eda y Salud Mental"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12609"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381\u2010022\u201005665\u20107"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583\u2010200109000\u201000004"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.70611","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T07:43:08Z","timestamp":1755070988000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.70611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/brb3.70611"],"URL":"https:\/\/doi.org\/10.1002\/brb3.70611","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.70611\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70611\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70611\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70611\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.70611\/v2\/decision1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2025-04-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70611"}}