{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:48:12Z","timestamp":1763038092795,"version":"3.43.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81641066","81760305"],"award-info":[{"award-number":["81641066","81760305"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Beta\u2010thalassemia major (\u03b2\u2010TM) is a hereditary blood disorder characterized by chronic anemia and hypoxia, which may have profound effects on brain function. This study systematically evaluates alterations in both intra\u2010brain network functional connectivity (FC) and inter\u2010network functional connectivity (FNC) in \u03b2\u2010TM patients using resting\u2010state functional magnetic resonance imaging (rs\u2010fMRI) and independent component analysis (ICA), aiming to uncover the potential mechanisms underlying their neurofunctional impairments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 72 \u03b2\u2010TM patients and 50 age\u2010 and gender\u2010matched healthy controls (HC). rs\u2010fMRI was used to collect brain functional data, and ICA was applied to extract 14 resting\u2010state functional networks (RSNs). Differences in FC within networks and FNC between the two groups were further compared to investigate the brain network abnormalities in \u03b2\u2010TM patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In \u03b2\u2010TM patients, FC within brain networks was significantly reduced in the anterior default mode network (aDMN), posterior default mode network (pDMN), left frontoparietal network (lFPN), right frontoparietal network (rFPN), ventral attention network (VAN), and executive control network (ECN). In contrast, FC was significantly increased in the dorsal sensorimotor network (dSMN) and posterior visual network (pVN). FNC analysis revealed that \u03b2\u2010TM patients exhibited enhanced connectivity between the lFPN and rFPN, as well as between the dorsal attention network (DAN) and VAN. However, connectivity was significantly weakened between the DAN and lFPN, ECN, auditory network (AN), and salience network (SN); as well as between the pVN and dSMN. These findings suggest impairments in cognitive control, attention allocation, and sensory integration, with specific disruptions in the SN that may contribute to the observed dysfunctions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Brain network abnormalities in \u03b2\u2010TM patients manifest as an alternating pattern of enhanced and weakened connectivity, revealing the profound impact of chronic anemia and hypoxia on cognitive, emotional, and sensory functions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.70614","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T04:10:27Z","timestamp":1750133427000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Study on Large\u2010Scale Brain Network Abnormalities in Patients With Beta\u2010Thalassemia"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9359-927X","authenticated-orcid":false,"given":"Mingrui","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Guangxi Medical University  Nanning China"},{"name":"Binzhou Medical University Hospital  Binzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guowei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Guangxi Medical University  Nanning China"},{"name":"NHC Key Laboratory of Thalassemia Medicine  Nanning 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