{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:24:52Z","timestamp":1785795892582,"version":"3.56.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["reference number 340\/2021"],"award-info":[{"award-number":["reference number 340\/2021"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Chitinase\u20103\u2010like protein 1 (CHI3L1) is a glycoprotein implicated in various neurological conditions. It is associated with neuroinflammation and tissue remodeling. The study aimed to validate the reference interval (RI) of serum (S) CHI3L1 in a control group, to correlate S CHI3L1 values with other biomarkers of neurodegenerative damage, and to estimate the diagnostic accuracy of S CHI3L1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Samples from 108 healthy volunteers were used to estimate the S CHI3L1 RI. For the comparison, we used cerebrospinal fluid (CSF) and serum (S) samples from 121 patients with cognitive disorders, and cognitive deterioration was assessed using the Mini\u2010Mental State Examination (MMSE). ELISA assays were used to determine the S CHI3L1, CSF, and S neurofilament light chain (NfL) levels; CSF and plasma \u03b2\u2010amyloid peptide\n                      <jats:sub>42<\/jats:sub>\n                      ; CSF and plasma \u03b2\u2010amyloid peptide\n                      <jats:sub>40<\/jats:sub>\n                      ; CSF total tau protein; CSF phosphorylated tau protein; and CSF alpha\u2010synuclein.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The estimated RI of S CHI3L1 was 14.44 to 63.11\u00a0\u00b5g\/L. The cut\u2010off value of S CHI3L1 was 34.37\u00a0\u00b5g\/L. ROC analysis showed that S CHI3L1 has 81.4% sensitivity and 76.9% specificity. We found a moderate Spearman's rank correlation coefficient between the S CHI3L1 and age (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>S\u00a0<\/jats:sub>\n                      =\u00a00.486;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and between S CHI3L1 and S NfL (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>S<\/jats:sub>\n                      \u00a0=\u00a00.489;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) in all groups. The Kruskal\u2013Wallis test showed a significant overall difference in S CHI3L1 among diagnostic groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.013). S CHI3L1 and CSF NfL had statistically significant effects on MMSE values (multiple\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      was 0.431).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results suggest that S CHI3L1 reflects the severity of cognitive deficits assessed by MMSE. It can be used as a supportive biomarker in neurodegenerative diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70619","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T02:41:14Z","timestamp":1749609674000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Chitinase\u20103\u2010Like 1 Protein (CHI3L1) Levels in Patients With Cognitive Deficits and Movement Disorders: Comparison With Other Biomarkers"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7326-6035","authenticated-orcid":false,"given":"R.","family":"Novobilsk\u00fd","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospital Ostrava  Ostrava Czech Republic"},{"name":"Department of Clinical Neurosciences University of Ostrava  Ostrava Czech Republic"},{"name":"Institute of Laboratory Medicine, Department of Clinical Biochemistry 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Czech Republic"},{"name":"Department of the Deputy Director for Science, Research, and Education University Hospital Ostrava  Ostrava Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bar","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Ostrava  Ostrava Czech Republic"},{"name":"Department of Clinical Neurosciences University of Ostrava  Ostrava Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Ku\u0161nierov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine University of Ostrava  Ostrava Czech Republic"},{"name":"Institute of Laboratory Medicine, Department of Clinical Biochemistry University Hospital Ostrava  Ostrava Czech 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