{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:02:23Z","timestamp":1772118143289,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005199","name":"Chinese Medicine Research Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2024ZL368"],"award-info":[{"award-number":["2024ZL368"]}],"id":[{"id":"10.13039\/501100005199","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Post\u2010stroke cognitive impairment (PSCI) is a common complication following stroke, with limited effective treatments. This randomized controlled trial aims to evaluate the efficacy of two non\u2010pharmacological interventions\u2014electroacupuncture therapy (EA) and herbal olfactory therapy (HOT)\u2014in improving cognitive function in PSCI patients, both as standalone treatments and in combination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This parallel\u2010group, assessor\u2010blinded, randomized controlled trial will recruit 210 PSCI patients, randomly assigned to one of six groups: control, EA, HOT, combination therapy, sham therapy, or the healthy (ratio 1:1:1:1:1:1). All participants will receive standard cognitive training and basic medical care. The EA group will receive 4 weeks of electro\u2010acupuncture at specific acupoints. The HOT group will receive 4 weeks of aromatic inhalation therapy using Acorus tatarinowii volatile oil. The combination group will receive both interventions. The primary outcome measure is cognitive function, assessed using the Montreal cognitive assessment (MoCA) at baseline, week 4, and week 8. Secondary outcomes include the mini\u2010mental state examination (MMSE), functional magnetic resonance imaging (fMRI), near\u2010infrared spectroscopy (fNIRS), and anxiety assessment using the state\u2010trait anxiety inventory (STAI) at baseline and week 4. Data analysis will be conducted using a modified intention\u2010to\u2010treat approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aims to evaluate the clinical efficacy of EA at cervical acupoints combined with HOT for PSCI, with a specific focus on determining the therapeutic superiority of this combined approach over monotherapy interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70631","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T07:10:39Z","timestamp":1751526639000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Therapeutic Effects of Acorus Tatarinowii Volatile Oil and Electroacupuncture in Post\u2010Stroke Cognitive Impairment Patients: A Clinical Trial Protocol"],"prefix":"10.1002","volume":"15","author":[{"given":"Ying","family":"Dandan","sequence":"first","affiliation":[{"name":"Shaoxing Second Hospital Medical Community General Hospital  Shaoxing Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao","family":"Jingting","sequence":"additional","affiliation":[{"name":"Center for Rehabilitation Medicine, Rehabilitation &amp; Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital Hangzhou Medical College  Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang","family":"Minzhe","sequence":"additional","affiliation":[{"name":"Center for Rehabilitation Medicine, Rehabilitation &amp; Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital Hangzhou Medical College  Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cai","family":"Zhuoyue","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Hangzhou Medical College  Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2793-3367","authenticated-orcid":false,"given":"Li","family":"Xinyun","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Hangzhou Medical College  Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1665-3"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2017.04.003"},{"issue":"1","key":"e_1_2_10_4_1","article-title":"Mini\u2010Mental State Examination (MMSE) for the Detection of Dementia in Clinically Unevaluated People Aged 65 and Over in Community and Primary Care Populations","volume":"2016","author":"Creavin S. T.","year":"2016","journal-title":"Cochrane Database of Systematic Reviews (Online)"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-7568(23)00217-9"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1274419"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00252-0"},{"key":"e_1_2_10_8_1","unstructured":"General nomenclature of science of acupuncture and moxibustion.2013. 164."},{"issue":"12","key":"e_1_2_10_9_1","first-page":"1240","article-title":"Therapeutic Observation of Acupuncture Combined With Chinese Medicine for Cognitive Impairment After Ischemic Stroke","volume":"2023","author":"Hei D.","year":"2023","journal-title":"Shanghai Journal of Acupuncture and Moxibustion"},{"issue":"5","key":"e_1_2_10_10_1","first-page":"372","article-title":"Progress in the Research on Therapeutic Effects of Resuscitation\u2010Inducing Aromatic Herbs of Traditional Chinese Medicine on Central Nervous System Diseases","volume":"45","author":"Hou X.","year":"2021","journal-title":"Progress in Pharmaceutical Sciences"},{"key":"e_1_2_10_11_1","unstructured":"International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use.Statistical Principles for Clinical Trials (E9). 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