{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:45:11Z","timestamp":1789753511447,"version":"4.0.1"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020084","name":"Guangzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020084","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Treatment of disorders of consciousness (DOC) remains a clinical challenge. Electroacupuncture (EA) was shown to have the potential to promote the recovery of consciousness. This trial aims to explore the therapeutic effects and mechanisms of EA in patients with DOC due to traumatic brain injury (TBI) through a multimodal approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 50 adult patients with DOC due to TBI and 25 healthy subjects will be enrolled in the study. Patients enrolled in the study will be assigned to the EA group or the sham\u2010EA group through stratified randomization. All patients receive behavioral assessments (CRS\u2010R and brain\u2013computer interface), neurophysiological evaluations (EEG, somatosensory evoked potentials, brainstem auditory evoked potentials), and neuroimaging evaluations (rs\u2010fMRI, amide proton transfer, intravoxel incoherent motion, neurite orientation dispersion and density imaging) before and after the 14\u2010day EA or sham\u2010EA treatment. Each healthy subject will receive a set of neurophysiological and neuroimaging examinations but no treatments. The practitioner administering EA and sham\u2010EA is the only one aware of the grouping results. In the sham\u2010EA group, sham\u2010acupoints, sham\u2010acupuncture, and sham\u2010wire are utilized. The primary outcome measurement is the change in CRS\u2010R score after 14 days of treatment compared with the baseline CRS\u2010R score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The AcuDoc trial will be the first randomized sham\u2010controlled study to investigate the clinical benefits of EA in patients with DOC. This trial will elucidate the role of EA in the treatment of DOC due to TBI and provide evidence of its therapeutic mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70637","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T03:11:16Z","timestamp":1750907476000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Electro\u2010Acupuncture to Treat Disorder of Consciousness (AcuDoc): Study Protocol for a Randomized Sham\u2010Controlled Trial"],"prefix":"10.1002","volume":"15","author":[{"given":"Kaiqi","family":"Lin","sequence":"first","affiliation":[{"name":"The Second Clinical Medical College of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jixiang","family":"Chen","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical College of Guangzhou University of Chinese 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