{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:57:57Z","timestamp":1793746677451,"version":"4.6.1"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Although the etiopathogenesis of generalized anxiety disorder (GAD) is not fully known, it is suggested that oxidative stress (OS) and estrogen play important roles. NADPH oxidase 1 (NOX1) is from the NADPH oxidase (NOX) family, which is known as a main source of reactive oxygen species (ROS). The G protein\u2010coupled estrogen receptor (GPER) is a novel estrogen receptor that mediates the non\u2010genomic rapid effects of estrogen. Recent work has shown GPER to be associated with OS, but it has not to our knowledge been examined in patient samples with GAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>We conducted a study comparing serum NOX1 and GPER levels of patients with GAD and healthy controls (HCs) matched for age, sex, and body mass index (BMI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Finding:<\/jats:title>\n                    <jats:p>We found increased NOX1 and decreased GPER levels in patients with GAD compared with HCs. In addition, we showed that serum NOX1 levels have very good diagnostic performance for patients with GAD. We observed a weak positive correlation between serum NOX1 levels and GPER levels in the patient group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although we believe these results are important for a better understanding of the role of OS and estrogen in GAD patients, longitudinal studies should be performed in larger samples of GAD patients grouped by severity of symptoms.We investigated the levels of NOX1 and GPER in patients with GAD. We found increased NOX1 and decreased GPER levels in patients with GAD compared to healthy controls. In addition, we showed that serum NOX1 levels have very good diagnostic performance for patients with GAD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70645","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T03:31:03Z","timestamp":1751859063000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Serum Nox1 and Gper Levels in Patients With Generalized Anxiety Disorder: A Cross\u2010Sectional Study in Turkiye"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7535-3562","authenticated-orcid":false,"given":"Onur","family":"Hur\u015fito\u011flu","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine Kahramanmaras Sutcu Imam University  Kahramanmaras Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erg\u00fcl Belge","family":"Kuruta\u015f","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine Kahramanmaras Sutcu Imam University  Kahramanmaras Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6mer Faruk","family":"Uygur","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine Ataturk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurinnisa","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine Ataturk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilal","family":"Uygur","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Erzurum Training and Research Hospital  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Saglam","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Siirt Training and Research Hospital  Siirt Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Strawbridge","sequence":"additional","affiliation":[{"name":"Centre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2121-20.2021"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2019.108494"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.07.023"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.130351"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2014.02.004"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2015.11.001"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.2018.16.1.88"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2016.04.098"},{"key":"e_1_2_8_10_1","first-page":"1","article-title":"Structured Clinical Interview for the DSM (SCID)","author":"First M. 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